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CNS Persistence of HIV-1 in Children: the Untapped Reservoir
Purpose of ReviewThe central nervous system (CNS) represents a potential HIV-1 reservoir that may need to be specifically targeted by remission...
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Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent...
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Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a...
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YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling
PurposeMembers of the aaRS (aminoacyl-tRNA synthetase) family are proteins controlling the aminoacylation process, in which YARS (tyrosyl-tRNA...
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Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish
Susceptible genetic polymorphisms and altered expression levels of protein kinase C (PKC)-encoding genes suggest overactivation of PKC in autism...
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Enhancing Diversity and Productivity of the HIV Behavioral Research Workforce through Research Education Mentoring Programs
Mentoring programs to enhance diversity in the HIV research workforce, using the research education grant mechanism (R25), were addressed to promote...
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Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders
Purpose of ReviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV...
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SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease
Dysfunctional RNA-binding proteins (RBPs) have been implicated in several neurodegenerative disorders. Recently, this paradigm of RBPs has been...
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Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND)
Purpose of ReviewThe purpose of this review is to summarize recent developments in PET imaging of neuropathologies underlying HIV-associated...
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Ketogenic diet, a potentially valuable therapeutic option for the management of refractory epilepsy in classical neonatal nonketotic hyperglycinemia: a case report
Nonketotic hyperglycinemia (NKH) is a devastating inborn error of glycine metabolism caused by deficient activity of the glycine cleavage enzyme....
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Molecular Signatures of HIV-1 Envelope Associated with HIV-Associated Neurocognitive Disorders
Purpose of ReviewThe HIV-1 envelope gene ( env ) has been an intense focus of investigation in the search for genetic determinants of viral entry and...
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The Range of Neurological Complications in Chikungunya Fever
BackgroundChikungunya fever is a globally spreading mosquito-borne disease that shows an unexpected neurovirulence. Even though the neurological...
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Effects of resveratrol pretreatment on endoplasmic reticulum stress and cognitive function after surgery in aged mice
BackgroundPostoperative cognitive dysfunction (POCD) seriously reduces quality of life and is associated with increased morbidity and mortality. The...
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Progressive Multifocal Leukoencephalopathy in HIV-Uninfected Individuals
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by the human neurotropic...
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Surveillance for severe hand, foot, and mouth disease from 2009 to 2015 in Jiangsu province: epidemiology, etiology, and disease burden
BackgroundSevere hand, foot, and mouth disease (HFMD) is a common childhood illness caused by various enteroviruses. The disease has imposed...
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Dementia in Down syndrome: unique insights for Alzheimer disease research
Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years. This association is...
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Emerging Causes of Arbovirus Encephalitis in North America: Powassan, Chikungunya, and Zika Viruses
Arboviruses are arthropod-borne viruses transmitted by the bite of mosquitoes, ticks, or other arthropods. Arboviruses are a common and an increasing...
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The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Tourette Disorder (TD) is a childhood-onset neuropsychiatric and neurodevelopmental disorder characterized by the presence of both motor and vocal...
