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The role of sphingolipids in psychoactive drug use and addiction
Psychoactive drug use is a common behavior in many societies worldwide, frequently associated with drug instrumentalization. Regular use may develop...
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Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally
BackgroundThe amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD)....
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Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Multiple sclerosis (MS) is a neurological autoimmune disorder of the central nervous system (CNS), characterized by recurrent episodes of...
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A cell culture model for investigation of synapse influenceability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid
SH-SY5Y neuroblastoma cells are frequently used for different neuronal cell culture models. As there is no “gold-standard”, miscellaneous protocols...
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Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis
Psychotic disorders affect ~3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis,...
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Guillain–Barré syndrome: a century of progress
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell...
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Inhibition of infarction-induced sympathetic innervation with endothelin receptor antagonism via a PI3K/GSK-3β-dependent pathway
Although endothelin (ET)-1 has been shown to upregulate nerve growth factor (NGF) expression, the molecular mechanisms are largely unknown....
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The phosphatase calcineurin regulates pathological TDP-43 phosphorylation
Detergent insoluble inclusions of TDP-43 protein are hallmarks of the neuropathology in over 90 % of amyotrophic lateral sclerosis (ALS) cases and...
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CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders
Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways....
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Effects of black cohosh on estrogen biosynthesis in hippocampus of non-human primates ex vivo in vitro and in human neuroblastoma cells in vitro
BackgroundEstrogens have neuroprotective properties. The aim of the study was to assess the impact of an isopropanolic extract of Cimicifuga racemosa...
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Reduced expression of voltage-gated Kv11.1 (hERG) K+ channels in aganglionic colon in Hirschsprung’s disease
PurposeThe pathophysiology of Hirschsprung’s disease (HSCR) is not entirely understood. There is no clear explanation for the occurrence of the...
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Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes
Genetic factors may underlie beneficial and adverse responses to antipsychotic treatment. These relationships may be easier to identify among...
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A common molecular signature in ASD gene expression: following Root 66 to autism
Several gene expression experiments on autism spectrum disorders have been conducted using both blood and brain tissue. Individually, these studies...
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Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [11C]SA4503
PurposeSigma-1 receptor ligands modulate the release of several neurotransmitters and intracellular calcium signaling. We examined the binding of a...
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Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression
BackgroundIntellectual disability (ID), autism, and epilepsy share frequent yet variable comorbidities with one another. In order to better...
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Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder
Several studies have reported that adults with major depressive disorder have shorter telomere length and reduced hippocampal volumes. Moreover,...
