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The Role of Neoadjuvant Immunotherapy in the Management of Merkel Cell Carcinoma with Clinically Detected Regional Lymph Node Metastasis
BackgroundImmunotherapy is emerging as a promising option for certain locally advanced and metastatic cutaneous malignancies. However, the role of...
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Defining Volume Targets for Regionalization of Pancreaticoduodenectomy, Esophagectomy, and Major Lung Resection Centers to Improve Oncologic and Surgical Outcomes
BackgroundPerformance of complex cancer surgeries at high-volume (HV) centers has been shown to reduce operative mortality. However, the case volume...
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Sufficient Regional Lymph Node Examination for Staging Adenocarcinoma of the Appendix
BackgroundThe presence of lymph node (LN) metastasis is a known negative prognostic factor in appendix cancer (AC) patients. However, currently the...
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Surgical Management of the Axilla in HR+/HER2– Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database
BackgroundAxillary management varies between sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) for patients with clinical...
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Perioperative Chemotherapy is Associated with Superior Overall Survival in Patients with Synchronous Colorectal Liver Metastases
BackgroundThe sequence of localized and systemic treatment for colorectal liver metastases (CRLM) remains debated. Our objective is to analyze the...
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Overall Survival Following Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy in Clinically Node Negative T1 Triple Negative Breast Cancer
BackgroundThe purpose of this study was to compare the overall survival (OS) of upfront surgery followed by adjuvant chemotherapy (ACT) versus...
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De-escalation of Post-mastectomy Irradiation in Hormone Receptor-Positive Breast Cancer with One to Three Positive Nodes
BackgroundThe 21-gene recurrence score (RS) is used to predict benefit from chemotherapy in hormone receptor (HR)-positive breast cancer with one to...
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National Practice Patterns in the Management of the Regional Lymph Node Basin After Positive Sentinel Lymph Node Biopsy for Cutaneous Melanoma
BackgroundImmediate completion lymph node dissection (CLND) for patients with sentinel lymph node (SLN) metastasis from cutaneous melanoma has been...
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A Clinical Decision Tool to Calculate Pretest Probability of Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma
BackgroundAlthough sentinel lymph node biopsy (SLNB) status is a strong prognostic indicator for cutaneous melanoma, unnecessary SLNBs have...
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National Trends in “Going Flat” After Mastectomy
IntroductionThe “Going Flat” movement became widely publicized in 2016 and provides information and support to women who choose to forego...
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Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database
BackgroundThis study compared survival between patients who had medullary thyroid cancer (MTC) treated with surgery alone and patients who underwent...
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Solid Pseudopapillary Tumor of the Pancreas: Is Enucleation Safe?
BackgroundWhile solid pseudopapillary tumor (SPT) of the pancreas are oncologically low-risk tumors, their resection with pancreaticoduodenectomy...
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Does Neoadjuvant Chemotherapy in Clinical T1–T2 N0 Triple-Negative Breast Cancer Increase the Extent of Axillary Surgery?
BackgroundCurrent management strategies for early-stage triple-negative breast cancer (TNBC) include upfront surgery to determine pathologic stage to...
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Temporal Trends and Factors Associated with Receipt of Post-mastectomy Radiation After Neoadjuvant Chemotherapy in Women with cT3 Breast Cancer
IntroductionGiven the potential impact of increasingly effective neoadjuvant chemotherapy (NACT) on post-mastectomy radiotherapy (PMRT)...
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Primary Breast Neuroendocrine Tumors: An Analysis of the National Cancer Database
BackgroundPrimary breast neuroendocrine tumors (BNETs) represent < 1% of breast cancers. Diagnosing BNETs can be challenging, and a limited amount of...
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Differences in the demographics, incidence, and survival of palmar and plantar acral melanoma: a population-based study
Acral melanoma (AM) has the worst prognosis of all cutaneous malignant melanomas (CMM). Differences between palmar and plantar tumors have not been...
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Impact of Medicaid Expansion on the Treatment and Outcomes of Intrahepatic Cholangiocarcinoma
IntroductionThe Affordable Care Act increased insurance coverage for patients residing in states that expanded Medicaid coverage, but its impact on...
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Demographic variations and time to initiation of adjunct treatment following surgical resection of anaplastic astrocytoma in the United States: a National Cancer Database analysis
Background and aimsThe aim of this study was to analyze the trends, demographic differences in the type and time to initiation (TTI) of adjunct...
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Contemporary Axillary Management in cT1–2N0 Breast Cancer with One or Two Positive Sentinel Lymph Nodes: Factors Associated with Completion Axillary Lymph Node Dissection Within the National Cancer Database
BackgroundManagement of the axilla in patients with cT1–2N0 breast cancer with one or two positive (+) sentinel lymph nodes (SLNs) is often debated,...
