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Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
BackgroundAcute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process...
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Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection
BackgroundIn HIV-1 infection, more than 95% of CD4 + T cells die of caspase-1 mediated pyroptosis. What governs the increased susceptibility of CD4 + T...
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Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response
Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The develo** adolescent brain is highly sensitive to...
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Mitochondrial neurogastrointestinal encephalomyopathy in a Pakistani female: a case report
BackgroundMitochondrial neurogastrointestinal encephalopathy is a rare multisystem autosomal recessive disease caused by mutations in the TYMP gene,...
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SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop
Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as...
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Idiopathic Hypersomnia in a Patient Suffering from MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes): a New Mitochondrial Feature?
Hypersomnia is a rare neurologic disorder characterized by an excessive daytime sleepiness with long naps, despite an undisturbed nocturnal sleep....
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Blood-based mitochondrial respiratory chain function in major depression
Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic...
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Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review
Purpose of ReviewReview the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed...
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Kynurenine and oxidative stress in children having learning disorder with and without attention deficit hyperactivity disorder: possible role and involvement
BackgroundThe etiological and pathophysiological factors of learning disorder (LD) and attention deficit hyperactivity disorder (ADHD) are currently...
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Neurexin 2 p.G849D variant, implicated in Parkinson’s disease, increases reactive oxygen species, and reduces cell viability and mitochondrial membrane potential in SH-SY5Y cells
Parkinson’s disease (PD) is a neurodegenerative movement disorder, affecting 1–2% of the human population over 65. A previous study by our group...
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Synaptic and mitochondrial mechanisms behind alcohol-induced imbalance of excitatory/inhibitory synaptic activity and associated cognitive and behavioral abnormalities
Alcohol consumption during pregnancy can significantly impact the brain development of the fetus, leading to long-term cognitive and behavioral...
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Mitochondrial modulators in the treatment of bipolar depression: a systematic review and meta-analysis
Mitochondrial dysfunction has been implicated in the risk, pathophysiology, and progression of mood disorders, especially bipolar disorder (BD)....
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The burden of mitochondrial disease with associated seizures: systematic literature reviews of health-related quality of life, utilities, costs and healthcare resource use data
BackgroundMitochondrial disease is a degenerative, progressive, heterogeneous group of genetic disorders affecting children and adults. Mitochondrial...
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Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease
Hemolysis, a crucial feature of Sickle cell disease (SCD), is a key player for cellular activation leading to various complications including...
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Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can...
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Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder
Environmental factors contribute to risk of bipolar disorder (BD), but how environmental factors impact the development of psychopathology within the...
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Acupuncture intervening depressive disorder: research progress in its neurobiological mechanism
Depressive disorder seriously affects people’s physical and mental health. Acupuncture is a safe and effective treatment for depression, yet, its...
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Potential causal association between gut microbiome and posttraumatic stress disorder
BackgroundThe causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to...
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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties
The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that...
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TFR1 knockdown alleviates iron overload and mitochondrial dysfunction during neural differentiation of Alzheimer’s disease-derived induced pluripotent stem cells by interacting with GSK3B
Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1)...
