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Cost Effectiveness of Watch and Wait Versus Resection in Rectal Cancer Patients with Complete Clinical Response to Neoadjuvant Chemoradiation
BackgroundWatch and wait (WW) protocols have gained increasing popularity for patients diagnosed with locally advanced rectal cancer and presumed...
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Tranexamic acid for the prevention of postpartum hemorrhage: a cost-effectiveness analysis
Postpartum hemorrhage is a significant contributor to maternal mortality worldwide and in the United States. Tranexamic acid (TXA) has been shown to...
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Comparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures
BackgroundOsteoporotic-related fractures represent an increasing burden to patients, health care systems and society.
AimsThis study estimated...
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The economic and health burden of stroke among younger adults in Australia from a societal perspective
BackgroundTo estimate the short term (5 years) and long term (30 years) economic burden of stroke among younger adults (18–64 years), and to...
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A Systematic Review of Methodologies Used in Models of the Treatment of Diabetes Mellitus
BackgroundDiabetes mellitus is a chronic and complex disease, increasing in prevalence and consequent health expenditure. Cost-effectiveness models...
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Development and application of the TFA macrosimulation model: a case study of modelling the impact of trans fatty acid (TFA) elimination policies in Brazil
IntroductionThe consumption of trans-fatty acids (TFA) is directly associated with cardiovascular disease risk and is responsible for a significant...
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Cost-Effectiveness of Hydroxyurea for Sickle Cell Anemia in a Low-Income African Setting: A Model-Based Evaluation of Two Dosing Regimens
Background and ObjectiveThe disease burden of sickle cell anemia (SCA) in sub-Saharan African (SSA) countries is substantial, with many children...
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The impact of high school athletic trainer services on medical payments and utilizations: a microsimulation analysis on medical claims
BackgroundIncreasing athletic trainer (AT) services in high schools has attracted widespread interest across the nation as an effective instrument to...
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Clinical and economic impact of molecular testing for BRAF fusion in pediatric low-grade Glioma
BackgroundTreatment personalization via tumor molecular testing holds promise for improving outcomes for patients with pediatric low-grade glioma...
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Exploring the impact of population ageing on the spread of emerging respiratory infections and the associated burden of mortality
BackgroundIncreasing life expectancy and persistently low fertility levels have led to old population age structures in most high-income countries,...
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Mortality associated with alternative primary healthcare policies: a nationwide microsimulation modelling study in Brazil
BackgroundBrazil’s Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world,...
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The health, cost and equity impacts of restrictions on the advertisement of high fat, salt and sugar products across the transport for London network: a health economic modelling study
BackgroundPolicies aimed at restricting the marketing of high fat, salt and sugar products have been proposed as one way of improving population diet...
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Sequential Multiple Assignment Randomized Trial (SMART) to identify optimal sequences of telemedicine interventions for improving initiation of insulin therapy: A simulation study
BackgroundTo examine the value of a Sequential Multiple Assignment Randomized Trial (SMART) design compared to a conventional randomized control...
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Cost-Effectiveness of Canagliflozin Added to Standard of Care for Treating Diabetic Kidney Disease (DKD) in Patients with Type 2 Diabetes Mellitus (T2DM) in England: Estimates Using the CREDEM-DKD Model
IntroductionOn the basis of reductions in diabetic kidney disease (DKD) progression and major adverse cardiovascular events observed in the landmark...
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Modelled Distributional Cost-Effectiveness Analysis of Childhood Obesity Interventions: A Demonstration
ObjectiveTo demonstrate how distributional cost-effectiveness analyses of childhood obesity interventions could be conducted and presented for...
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Rapid elimination of cervical cancer while maintaining the harms and benefits ratio of cervical cancer screening: a modelling study
BackgroundHuman papillomavirus (HPV) vaccination and intensifying screening expedite cervical cancer (CC) elimination, yet also deteriorate the...
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Research on layout model and construction planning of aged care institutions for disabled elders in China: based on Nan**g city data
BackgroundTo meet the needs of diversified pension services and the construction of aged care institutions is one of the urgent livelihood issues in...
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Calibrating Natural History of Cancer Models in the Presence of Data Incompatibility: Problems and Solutions
The calibration of cancer natural history models is often challenged by a lack of representative calibration targets, forcing modellers to rely on...
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Designing a generic, adaptive protocol resource for the measurement of health impact in cash transfer pilot and feasibility studies and trials in high-income countries
IntroductionIn the context of the COVID-19 pandemic, upstream interventions that tackle social determinants of health inequalities have never been...
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Prediction of complications in health economic models of type 2 diabetes: a review of methods used
AimDiabetes health economic (HE) models play important roles in decision making. For most HE models of diabetes 2 diabetes (T2D), the core model...
