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Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma
We investigated the cytolytic and mechanistic activity of anti-CD19 chimeric antigen receptor natural killer (CD19.CAR.NK92) therapy in lymphoma cell...
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Neue Methoden der multiparametrischen Gewebediagnostik
In recent years, various methods of multiparametric tissue diagnostics have been developed that allow a detailed molecular, cellular, and...
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SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives
Purpose of ReviewAn emerging subset of dismal sinonasal cancers are those characterized by the loss of a SWItch/Sucrose Non-Fermentable (SWI/SNF)...
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Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU
Purpose of ReviewAntimicrobial resistance continues to increase throughout the world, with the impact on critically ill children in low- and...
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Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis
IntroductionThe terminal complement C5 inhibitor ravulizumab has a long elimination half-life, allowing maintenance dosing every 8 weeks. In the...
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Single-cell transcriptomics for the assessment of cardiac disease
Cardiovascular disease is the leading cause of death globally. An advanced understanding of cardiovascular disease mechanisms is required to improve...
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Influence of a hyaluronan-binding system for sperm selection in intracytoplasmic sperm injection cycles on embryo morphokinetic parameters and in vitro fertilization cycle outcomes
PurposeAlthough the impact of the paternal contribution to embryo quality and blastocyst formation is a well-known phenomenon, the current literature...
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Optimized sperm selection: a highly efficient device for the isolation of progressive motile sperm with low DNA fragmentation index
PurposeTo identify the sperm preparation procedure that selects the best sperm population for medically assisted reproduction.
MethodsProspective...
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Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer
Metastasis is the leading cause of cancer-related deaths of breast cancer patients. Some cancer cells in a tumour go through successive steps,...
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Cardiac splicing as a diagnostic and therapeutic target
Despite advances in therapeutics for heart failure and arrhythmias, a substantial proportion of patients with cardiomyopathy do not respond to...
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Circulating Tumor Cells: State-of-the-art Update on Technologies and Clinical Applications
Purpose of ReviewCirculating tumor cells represent rare events in the peripheral blood of patients with cancer that can provide insight into tumor...
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RNA-based antibiotic susceptibility testing of tmexCD-toprJ-mediated tigecycline resistance in Klebsiella pneumoniae
The emergence and prevalence of plasmid-encoded RND-type efflux pump TMexCD-TOprJ severely compromise tigecycline treatment, which is recognized as...
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Pituitary stem cells: past, present and future perspectives
Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary...
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Simulating nature in sperm selection for assisted reproduction
Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000 sperm out of millions in an ejaculate reach the fallopian...
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Perivascular invasion of primary human glioblastoma cells in organotypic human brain slices: human cells migrating in human brain
IntroductionGlioblastoma (GBM) is an aggressive primary brain cancer. Lack of effective therapy is related to its highly invasive nature. GBM...
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The use of fresh compared to frozen ejaculated sperm has no impact on fresh embryo transfer cycle reproductive outcomes
PurposeTo compare the reproductive outcomes of fresh embryo transfer (ET) cycles utilizing fresh versus frozen ejaculated sperm.
Methods ... -
In cases with raised sperm DNA fragmentation, can sperm selection by magnetic-activated cell sorting or testicular sperm aspiration help improve reproductive outcomes?
PurposeTo evaluate the efficacy of magnetic-activated cell sorting (MACS) or testicular sperm aspiration (TESA) to improve reproductive outcomes in...
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Sperm Preparation with Microfluidic Sperm Sorting Chip May Improve Intracytoplasmic Sperm Injection Outcomes Compared to Density Gradient Centrifugation
Does sperm preparation using the FERTILE PLUS™ Sperm Sorting Chip improve fertilization rates, blastocyst formation, utilization, and euploidy rates...
