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Precision Medicine and Clinical Trials in Advanced and Metastatic Oral Cancer
PurposeOral cancer is a significant global health concern, with high morbidity and mortality rates, particularly in regions with prevalent tobacco...
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Controversies and Challenges in the Management of Osteosarcoma—an Indian Perspective
Osteosarcoma (OGS) is the most common primary bone tumor in children and adolescents which requires a multidisciplinary approach to management....
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Maintenance Treatment in Acute Lymphoblastic Leukemia: A Clinical Primer
Cure rates in pediatric acute lymphoblastic leukemia (ALL) currently approach 90% in the developed world. Treatment involves 6-8 mo of intensive...
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Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma
PurposeOptimization of local therapies in synovial sarcoma (SS) considered unresectable at diagnosis is needed. We evaluated the effects of...
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Macrophages and angiogenesis in human lymphomas
A link exists between chronic inflammation and cancer and immune cells, angiogenesis, and tumor progression. In hematologic malignancies,...
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Role of Virus-Directed Therapy in Soft Tissue Sarcoma
Bone and soft tissue sarcoma are rare cancers of mesenchymal origin with the characteristics of heterogeneity and diversity that account for less...
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Impact of magnetic resonance imaging-derived skeletal muscle index in locoregionally advanced nasopharyngeal carcinoma
PurposeTo evaluate the clinical implication of magnetic resonance imaging (MRI)-derived skeletal muscle index (SMI) in locoregionally advanced...
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Patient Burden and Real-World Management of Chemotherapy-Induced Myelosuppression: Results from an Online Survey of Patients with Solid Tumors
IntroductionChemotherapy-induced myelosuppression (CIM) is one of the most common dose-limiting complications of cancer treatment, and is associated...
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Metronomic capecitabine combined with aromatase inhibitors for new chemoendocrine treatment of advanced breast cancer: a phase II clinical trial
PurposeThis study was designed to determine the safety and clinical efficacy of metronomic chemotherapy combined with aromatase inhibitors (AIs) for...
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CAG (cytarabine, aclarubicin and granulocyte colony-stimulating factor) regimen for core binding factor acute myeloid leukaemia with measurable residual disease
Acute myeloid leukaemia (AML) with t (8;21) or inv (16), called core binding factor (CBF) AML, has a favourable prognosis. However, some CBF-AML...
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Progress in the Treatment of Small Intestine Cancer
Small intestine cancer is rare, accounting for approximately 3% of all gastrointestinal malignancies. The most common histological subtypes include...
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Cutaneous Lesions in a Patient with Cancer
A 61-year-old male with a diagnosis of squamous cell carcinoma (SCC) of the oral cavity with pulmonary metastases was referred to us for palliative...
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Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor characterized by a specific DNA...
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Narrative Review of Multidisciplinary Management of Central Nervous Involvement in Patients with HER2-Positive Metastatic Breast Cancer: Focus on Elderly Patients
The tumor biology of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) promotes the development of central nervous system...
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Immunotherapy and Biomarkers in Sarcoma
Sarcoma describes a rare and heterogeneous group of diseases. Current treatment options for metastatic sarcoma are quite limited. Conventional...
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Phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced breast cancer
Breast cancer is one the most common cause of cancer death in women worldwide. We report here the first phase II study investigating a virus...
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Clinical and molecular characteristics of pediatric low-grade glioma complicated with ventriculo-peritoneal shunt related ascites
IntroductionVentriculo-peritoneal shunt (VPS) related ascites is a rare complication of pediatric low grade gliomas (pLGG). Physiopathology of this...
