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Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice
Aims/hypothesisLysophosphatidic acid (LPA) is a lipid mediator produced by adipocytes that acts via specific G-protein-coupled receptors; its...
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Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy
The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent...
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Anti-Fibrosis Therapy and Diabetic Nephropathy
Diabetes mellitus is rapidly becoming a global health issue that may overtake cancer during the next two decades as it covertly affects multiple...
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Fibrosis in systemic sclerosis: common and unique pathobiology
Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated with autoimmunity and proliferative/obliterative vasculopathy, shares...
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Cyclic regulation of LPA3 in human endometrium
BackgroundLysophosphatidic acid (LPA) belongs to the group of lipid messengers, which plays a pivotal role in the establishment of implantation via...
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Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression
Lysophosphatidic acid (LPA), produced extracellularly by autotaxin (ATX), has diverse biological activities implicated in tumor initiation and...
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Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root
BackgroundIn our present study, we studied the role of demyelination of the trigeminal nerve root in the development of prolonged nociceptive...
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Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells
Lysophosphatidic acid (LPA), which is a bioactive phospholipid, interacts with specific G protein-coupled transmembrane receptors. Recently,...
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Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine
BackgroundAlthough neuropathic pain is frequently observed in demyelinating diseases such as Guillain-Barré syndrome and multiple sclerosis, the...
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Metastasis-suppressor genes in clinical practice: lost in translation?
Over the past 25 years, an expanding set of metastasis-suppressor genes (MSGs) has been identified that specifically regulate metastasis formation...
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Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer
Sphingosine kinase 1 (SK1) is a lipid enzyme with oncogenic properties that converts the proapoptotic lipid sphingosine into the antiapoptotic lipid...
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Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCϵ pathway in dorsal root ganglion neurons
BackgroundIt has been demonstrated that lysophosphatidic acid (LPA) released from injury tissue and transient receptor potential vanilloid 1 (TRPV1)...
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Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis
Phosphoinositide 3-kinase γ (PI3Kγ) consists of a catalytic subunit p110γ, which forms mutually exclusive dimers with one of the regulatory subunits...
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Molecular Targeted Therapy in Ovarian Cancer
Over the past two decades, empirical optimization of cytotoxic chemotherapy combinations and surgical debulking procedures have improved outcomes and...
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Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain
BackgroundCyclic phosphatidic acid (cPA) is a structural analog of lysophosphatidic acid (LPA), but possesses different biological functions, such as...
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Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive lysophospholipids that affect various cellular processes through G...
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Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management
Interstitial lung disease (ILD) is a challenging clinical entity associated with multiple connective tissue diseases, and is a significant cause of...
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The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells
We have previously shown that high expression levels of the lipid kinase sphingosine kinase-1 (SphK1) correlate with poor survival of glioblastoma...
