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3D Bioprinting-Based Dopamine-Coupled Flexible Material for Nasal Cartilage Repair
IntroductionSince 3D printing can be used to design implants according to the specific conditions of patients, it has become an emerging technology...
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Low-intensity vestibular noise stimulation improves postural symptoms in progressive supranuclear palsy
BackgroundPostural imbalance and falls are an early disabling symptom in patients with progressive supranuclear palsy (PSP) of multifactorial origin...
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Increased levels of regulatory T cells and IL-10-producing regulatory B cells are linked to improved clinical outcome in Parkinson’s disease: a 1-year observational study
Whilst the contribution of peripheral and central inflammation to neurodegeneration in Parkinson’s disease and the role of the immune response in...
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Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
Due to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC)...
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Initial results of a phase II trial of 18F-DOPA PET-guided re-irradiation for recurrent high-grade glioma
PurposeIn-field high-grade glioma (HGG) recurrence is a common challenge with limited treatment options, including re-irradiation. The radiotracer...
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From lab bench to hope: a review of gene therapies in clinical trials for Parkinson’s disease and challenges
Parkinson's disease (PD) is a chronic neurological disorder that is identified by a characteristic combination of symptoms such as bradykinesia,...
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The impact of 18F-FDOPA-PET/MRI image fusion in detecting liver metastasis in patients with neuroendocrine tumors of the gastrointestinal tract
BackgroundThis study assesses the value of image fusion using 18F-fluoro-L-DOPA (18F-DOPA) positron emission tomography (PET) and magnetic resonance...
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Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l -3,4-dihydroxyphenylalanine ( l -DOPA)....
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Impact of deep brain stimulation therapy on the vertebral sagittal balance in Parkinson’s disease patients
Parkinson’s disease (PD) is characterized by cardinal motor signs: 4–6 Hz resting tremor, rigidity, and bradykinesia. In addition, 3–18% of PD...
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Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and its treatment remains a big challenge. The pathogenesis...
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Serotonergic targets for the treatment of l-DOPA-induced dyskinesia
Dopamine (DA) replacement therapy with l -3,4-dihydroxyphenylalanine ( l -DOPA) continues to be the gold-standard treatment for Parkinson’s disease...
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High-resolution ultrasound changes of the vagus nerve in idiopathic Parkinson’s disease (IPD): a possible additional index of disease
Background and rationaleHistopathological studies revealed degeneration of the dorsal motor nucleus of the vagus nerve (VN) early in the course of...
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Demenz mit Lewy-Körpern: alte und neue Erkenntnisse – Teil 2: Behandlung
BackgroundThe treatment of patients with dementia with Lewy bodies (DLB) is multifaceted, as motor symptoms, cognitive symptoms, behavioral and...
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Pupillometry as an indicator of l-DOPA dosages in Parkinson’s disease patients
Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as...
