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Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway
PurposeCervical cancer is the fourth most common cancer in women and poses a major threat to women's health, urgently requiring new treatment methods.
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Ultrastructural and morphological analysis during progression of Bowen disease reveals a complex interplay between hyperkeratosis, cytokeratin expression, host immunity and amyloid deposition
BackgroundBowen disease, one of the common skin cancers, is defined as squamous cell carcinoma in situ , characterized by atypical keratinocytes...
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Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues
Dystonin ( DST ), also known as bullous pemphigoid antigen 1 ( BPAG1 ), encodes cytoskeletal linker proteins belonging to the plakin family. The DST gene...
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Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup
Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular...
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Synchronous bilateral idiopathic external auditory canal cholesteatoma: a case report and review of the literature
BackgroundExternal auditory canal cholesteatoma (EACC) is a rare pathological condition representing 0.1% of all new otologic cases. Bilaterality...
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EWSR1-WT1 gene fusions in neoplasms other than desmoplastic small round cell tumor: a report of three unusual tumors involving the female genital tract and review of the literature
Desmoplastic small round cell tumor (DSRCT) is a high-grade round cell sarcoma that typically arises in the abdominopelvic cavity of young males,...
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Adenoid cystic carcinoma metastatic to the kidney: a series of 10 patients emphasizing unilateral presentation and long time interval from primary diagnosis
Adenoid cystic carcinoma (AdCC) metastasis to kidney is rare. We identified 10 patients with metastatic AdCC in multi-institutional collaboration....
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Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis
Tumors with papillary cribriform and morular architecture were initially considered to be variants of papillary thyroid carcinoma; however, recent...
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Applications of Ultraviolet and Sub-ultraviolet Dermatoscopy in Neoplastic and Non-neoplastic Dermatoses: A Systematic Review
Dermatoscopy is a non-invasive and cost-efficient imaging technique augmenting clinical examination in neoplastic and non-neoplastic dermatoses....
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Grundlagen der Pathologie seltener Hodentumoren
The most common group of testicular tumours comprises germ cell tumours. Other primary testicular tumours are rare, but it is important to be aware...
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Aggressive Oral Carcinoma Cuniculatum Presenting with Recurrence and Metastasis: A Case Report
Oral carcinoma cuniculatum (OCC) is an uncommon and distinctive variant of oral squamous cell carcinoma affecting the oral cavity. It commonly arises...
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Gastroblastoma with a novel ACTB::GLI1 gene fusion in a 19-year-old male
Gastroblastoma is a rare gastric biphasic tumor composed of mesenchymal and epithelial elements in variable proportions. These tumors usually arise...
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FNA of Meningioma with Rhabdoid Features Presenting as a Lateral Neck Mass
Primary meningioma at extracranial head and neck sites is uncommon. Since fine needle aspiration (FNA) is often the first line diagnostic modality...
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Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology
Cells in human milk are an untapped source, as potential “liquid breast biopsies”, of material for investigating lactation physiology in a...
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CUP-Syndrom – Diagnostik aus Sicht der Pathologie
ProblemHistologic and immunohistologic workup of tumor material from metastases of a previously unknown primary tumor is important for identifying...
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Variability of serum CYFRA 21 − 1 and its susceptibility to clinical characteristics in individuals without cancer: a 4-year retrospective analysis
BackgroundCYFRA 21 − 1 is a useful marker for diagnosing and monitoring lung cancer. However, its stability remains unclear. Moreover, while its...
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Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1
BackgroundPsoriasis is a common inflammatory skin disease. Abnormal proliferation of keratinocytes is one of the psoriatic histopathological...
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Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma
Spindle cell squamous cell carcinoma (SpC-SCC) is rare, accounting for 0.4–4% of head and neck (HN) SCCs. Better understanding of HN SpC-SCC...
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Laparoscopic transabdominal approach for resection of presacral epidermoid cyst in an obese man: a case report
BackgroundComplete resection of presacral epidermoid cysts is recommended due to the potential for infection or malignancy. Transsacral and...
