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The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells
N6-methyladenosine (m6A) modification is involved in diverse immunoregulation, while the relationship between m6A modification and immune tolerance...
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Five critically ill pregnant women/parturients treated with extracorporeal membrane oxygenation
BackgroundMaternal mortality has always been a major medical concern. Recently, the successful application of extracorporeal membrane oxygenation...
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Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?
Dysbiosis corresponds to the disruption of a formerly stable, functionally complete microbiota. In the gut, this imbalance can lead to adverse health...
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Multimodality management for chronic subdural hematoma in China: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study
BackgroundDespite its prevalence, there is ongoing debate regarding the optimal management strategy for chronic subdural hematoma (CSDH), reflecting...
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Reconstitution of peripheral blood T cell receptor β immune repertoire in immune checkpoint inhibitors associated myocarditis
PurposeImmune checkpoint inhibitors (ICIs)-associated myocarditis was a rare yet severe complication observed in individuals undergoing...
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USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination
BackgroundMetadherin (MTDH) and ubiquitin specific protease 7 (USP7) have been identified to involve in the tumorigenesis of cervical cancer (CC)....
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A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome
Purpose of ReviewIndividuals with Down syndrome (DS) may be more susceptible to oral disorders as a result of a combination of genetic factors,...
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IRAK-M has effects in regulation of lung epithelial inflammation
BackgroundEpithelial barrier is important for asthma development by sha** immune responses. Airway expressing-IL-1 receptor-associated kinase...
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Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice
BackgroundStaphylococcus aureus ( S. aureus ) arthritis is one of the most detrimental joint diseases known and leads to severe joint destruction...
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Mechanistic and therapeutic links between rheumatoid arthritis and diabetes mellitus
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and irreversible cartilage and bone...
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Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies
The association between breastfeeding and the occurrence of allergic rhinitis (AR) and food allergy (FA) in offspring remains inconclusive. This...
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Human umbilical cord mesenchymal stem cell-derived exosomes promote microcirculation in aged diabetic mice by TGF-β1 signaling pathway
BackgroundMicrovascular dysfunction is one of the most common pathological characteristics in Type 2 diabetes. Human mesenchymal stem cell-derived...
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Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network
BackgroundWe showed previously that allergic reactivity to ovalbumin (OVA) could be regulated in mice following perturbation of immune networks using...
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Mesenchymal stem cells (MSCs) in Leber’s hereditary optic neuropathy (LHON): a potential therapeutic approach for future
BackgroundOptic neuropathy has become a new typical syndromic multi-system disease that leads to optic atrophy. This review discusses potential...
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Immunomodulatory effects of atorvastatin on MRL/lpr mice
BackgroundStatins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel...
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The effect of incretin-based drugs on the riks of acute pancreatitis: a review
ObjectivesIn recent years, new hypoglycaemic drugs that affect the incretin system have become increasingly popular in the treatment of type 2...
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An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer
BackgroundCancer-derived exosomes contribute significantly in intracellular communication, particularly during tumorigenesis. Here, we aimed to...
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Relationship between [123I]FP-CIT SPECT data and peripheral CD4 + T cell profile in newly-diagnosed drug-naïve Parkinson’s disease patients
BackgroundDysregulation of the CD4 + T cell compartment occurs in Parkinson’s Disease (PD). Nonetheless, the exact relationship with dopamine...
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IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch promotes angiogenesis in transplanted flap and inhibits inflammatory response
Skin flap transplantation is one of the most common tissue transplantation methods for wound repair and organ reconstruction in plastic surgery....
