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High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer
PurposeAlthough the DNA repair mechanism is important in preventing carcinogenesis, its activation in established cancer cells may support their...
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DNA repair pathways in breast cancer: from mechanisms to clinical applications
BackgroundBreast cancer (BC) is a complex disease with various subtypes and genetic alterations that impact DNA repair pathways. Understanding these...
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Recent advances in the treatment for gynecologic oncology
This commentary summarized the most important findings in the first half 2023 year based on Society of Gynecologic Oncology (SGO) annual meeting and...
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HRD effects on first-line adjuvant chemotherapy and PARPi maintenance therapy in Chinese ovarian cancer patients
Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit...
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AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis
While alterations in nucleus size, shape, and color are ubiquitous in cancer, comprehensive quantification of nuclear morphology across a whole-slide...
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Resistance to Poly (ADP-Ribose) Polymerase Inhibitors (PARPi): Mechanisms and Potential to Reverse
Purpose of ReviewThis review will focus on the most common mechanisms for poly (ADP-ribose) polymerase inhibitors’ (PARPi) resistance and the main...
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Complete Response Following Treatment with Olaparib in a Patient with BRCA-Mutant High-Grade Serous Ovarian Cancer and Central Nervous System Metastases
Ovarian cancer is the leading cause of death from gynaecological cancers worldwide. High-grade serous ovarian cancer is the most frequent and...
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Role of PARP inhibitors beyond BRCA mutation and platinum sensitivity in epithelial ovarian cancer: a meta-analysis of hazard ratios from randomized clinical trials
BackgroundPARP inhibitors (PARPi) have a well-established role in platinum-sensitive ovarian cancer (PSOC), in BRCA mutant (BRCAm), and homologous...
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Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy
BackgroundCellular senescence is growing in popularity in cancer. A dual function is played by the senescence-associated secretory phenotype (SASP)...
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Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer
Clonal hematopoiesis (CH) driven by mutations in the DNA damage response (DDR) pathway is frequent in patients with cancer and is associated with a...
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Cost-effective genoty** for classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) in resource-poor settings: multiplex ligation probe amplification (MLPA) with/without sequential next-generation sequencing (NGS)
PurposeGenoty** of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is becoming increasingly significant...
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Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian...
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Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report
BackgroundPrecision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to...
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Synergistic lethality between PARP-trap** and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells
PARP1 and PARP2 play critical roles in regulating DNA repair and PARP inhibitors have been approved for the treatment of BRCA1/2-mutated ovarian and...
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Clinical application of PARP inhibitors in ovarian cancer: from molecular mechanisms to the current status
As a kind of gynecological tumor, ovarian cancer is not as common as cervical cancer and breast cancer, but its malignant degree is higher. Despite...
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A new wave of innovations within the DNA damage response
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance...
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Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors
Poly[ADP-ribose] polymerase (PARP) inhibitors, which selectively kills homologous recombination (HR) repair-deficient cancer cells, are widely...
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Maintenance therapy for newly diagnosed epithelial ovarian cancer– a review
Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer among women worldwide, with the 5-year survival rate ranging between 30 and...
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Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice
Sirtuin-1 (SIRT1) is involved in various metabolic pathways, including fatty acid synthesis and gluconeogenesis in the liver. However, its role in...
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Budget Impact Analysis of Olaparib in Combination with Bevacizumab for Maintenance Therapy for Ovarian Cancer in Argentina
ObjectivesTo perform a budget impact analysis (BIA) of introducing olaparib as maintenance therapy in women who have BRCA mutations (BRCAm) with...
