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Silencing LncRNA SNHG16 suppresses the diabetic inflammatory response by targeting the miR-212-3p/NF-κB signaling pathway
BackgroundLong noncoding RNAs (LncRNAs) have been identified to play an important role in diabetes. The aim of the present study was to determine the...
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Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility
BackgroundLong non-coding RNAs (lncRNAs) have a size of more than 200 bp and are known to regulate a host of crucial cellular processes like...
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Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated with cancer is partially due to the lack of reliable...
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Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance
Breast cancer is the most common cancer, and the second cause of cancer-related deaths (after lung cancer) among women. Develo** tumor metastasis...
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Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis
Molecular-based classifications of gastric cancer (GC) were recently proposed, but few of them robustly predict clinical outcomes. While mutation and...
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Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells
The functions and molecular mechanisms of long noncoding RNA (lncRNA) in reproduction have been widely studied at present. However, lncRNA regulating...
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Signaling cascades in the failing heart and emerging therapeutic strategies
Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high mortality rate worldwide, chronic heart failure is one...
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lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression
lncRNA ZNF593 antisense (ZNF593-AS) transcripts have been implicated in heart failure through the regulation of myocardial contractility. The...
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The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial...
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Landscape of NcRNAs involved in drug resistance of breast cancer
Breast cancer (BC) leads to the most amounts of deaths among women. Chemo-, endocrine-, and targeted therapies are the mainstay drug treatments for...
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LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are effective targeted therapy drugs for advanced non-small cell lung...
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Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy
Long noncoding RNAs (lncRNAs) are endogenous RNA transcripts longer than 200 nucleotides which regulate epigenetically the expression of genes but do...
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A Novel lncRNA lncRNA-4045 Promotes the Progression of Hepatocellular Carcinoma by Affecting the Expression of AKR1B10
BackgroundLong noncoding RNAs (lncRNAs) have been shown to be related to the occurrence and development of a variety of cancers including...
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The regulation of protein translation and its implications for cancer
In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins...
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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival,...
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H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas
Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular...
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Lens epithelium cell ferroptosis mediated by m6A-lncRNA and GPX4 expression in lens tissue of age-related cataract
BackgroundIn the present study, we explored the role of N 6 -methyladenosine (m 6 A) modification of long non-coding RNAs (lncRNAs) and its association...
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Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic cells in the bone marrow (BM). It is a highly heterogeneous...
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Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets
BackgroundIt has been suggested that dysregulation of long non-coding RNAs (lncRNAs) could be associated with the incidence and development of...
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LncRNA SNHG3 Facilitates the Malignant Phenotype of Cholangiocarcinoma Cells via the miR-3173–5p/ERG Axis
BackgroundLong noncoding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) is an oncogenic lncRNA that has been reported in many cancers, but the...
