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Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection
Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public...
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Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction
BackgroundEarly dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative...
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Assessment of wound healing efficacy of Growth Factor Concentrate (GFC) in non-diabetic and diabetic Sprague Dawley rats
BackgroundsThe investigation of wound healing potential of human GFC (growth factor concentrate) was undertaken in diabetic and non-diabetic rats....
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Hemoglobin-induced continuous activation of macrophages in endometriotic cysts: a potential mechanism of endometriosis development and carcinogenesis
Endometriosis is a chronic inflammatory disease. Endometriotic cysts contain hemoglobin (Hb) and infiltrated macrophages, indicating that the...
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Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year survival rate of 6% following a diagnosis, and novel...
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Role of zinc in health and disease
This review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and...
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Role of CD4+ T-cells for regulating splenic myelopoiesis and monocyte differentiation after experimental myocardial infarction
Myocardial infarction (MI) induces the generation of proinflammatory Ly6C high monocytes in the spleen and the recruitment of these cells to the...
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Intra-ovarian inflammatory states and their associations with embryo quality in normal-BMI PCOS patients undergoing IVF treatment
BackgroundPolycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility in women of reproductive age, and low-grade chronic...
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Interrogating the sepsis host immune response using cytomics
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be...
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Immune Competence and Pain: A Narrative Review
Purpose of ReviewThis review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the...
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Immunotherapy for recurrent or metastatic nasopharyngeal carcinoma
Immunotherapy, particularly immune checkpoint inhibitors (ICIs), such as anti-programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) therapy, has...
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Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy
Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging therapeutic modality for the treatment of inflammatory bowel disease...
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Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review
Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow...
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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and...
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Hypersensitivity and lymphocyte activation after total hip arthroplasty
In the last decades total hip arthroplasty (THA) has become a standard procedure with many benefits but also a few still unsolved complications,...
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Wuhan 3 years after the outbreak of the pandemic—cardiological insights and perspectives
In November 2019, Wuhan, a city in Central China, became the center of an outbreak of pneumonia of unknown cause, which was later named “coronavirus...
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Advances in hematopoietic stem cells ex vivo expansion associated with bone marrow niche
Hematopoietic stem cells (HSCs) are an ideal source for the treatment of many hematological diseases and malignancies, as well as diseases of other...
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A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
BackgroundMantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma subtype which remains incurable despite multimodal approach including...
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Group 3 innate lymphoid cells secret neutrophil chemoattractants and are insensitive to glucocorticoid via aberrant GR phosphorylation
BackgroundPatients with neutrophil-mediated asthma have poor response to glucocorticoids. The roles and mechanisms of group 3 innate lymphoid cells...
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Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice...
