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Tocilizumab in chronic active antibody-mediated rejection: rationale and protocol of an in-progress randomized controlled open-label multi-center trial (INTERCEPT study)
BackgroundChronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause...
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Translating B cell immunology to the treatment of antibody-mediated allograft rejection
Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes ~50% of kidney allograft losses each year. Despite attempts to develop...
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Ruxolitinib is an effective salvage treatment for multidrug-resistant graft-versus-host disease after haploidentical allogeneic hematopoietic stem cell transplantation without posttransplant cyclophosphamide
The purpose of our study is to identify the efficacy of ruxolitinib in human leukocyte antigen (HLA) haploidentical hematopoietic stem cell...
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Meniscal resection increases the risk of residual knee laxity even in patients undergoing anatomic double-bundle anterior cruciate ligament reconstruction with eight strands of hamstring autografts
PurposeTo compare the midterm clinical outcomes of different meniscal surgeries in patients undergoing anatomic double-bundle anterior cruciate...
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Activation of immune signals during organ transplantation
The activation of host’s innate and adaptive immune systems can lead to acute and chronic graft rejection, which seriously impacts graft survival....
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Bone filling decreases donor site morbidity after anterior cruciate ligament reconstruction with bone–patellar tendon–bone autografts
PurposeBone–patellar tendon–bone (BTB) autograft remains the most widely used graft source for anterior cruciate ligament reconstruction (ACLR). The...
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Activation and regulation of alloreactive T cell immunity in solid organ transplantation
Transplantation is the only curative treatment for patients with kidney failure but it poses unique immunological challenges that must be overcome to...
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Socket Preservation in Dentistry: a Comprehensive Review on Efficacy, Tissue Volume Maintenance, and Economic Considerations with Focus on Membrane Types and Bone Regeneration Dynamics
Purpose of the ReviewSocket preservation post-tooth extraction is crucial for optimal conditions for subsequent dental implant placement. This review...
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The Whitaker test: a predictive tool for evaluating the surgical efficacy of upper urinary tract reconstruction in patients carrying a nephrostomy tube after surgery
PurposeTo explore the role of the Whitaker test in evaluating the postoperative outcome of upper urinary tract reconstruction surgery in patients...
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Superior graft maturation after anatomical double-bundle anterior cruciate ligament reconstruction using the transtibial drilling technique compared to the transportal technique
PurposeTo evaluate and compare the femoral tunnel aperture position, graft bending angle and the magnetic resonance imaging (MRI) graft signal...
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Transition of young adult kidney transplant recipients
Survival of pediatric kidney transplant recipients has improved over the past six decades. However, adolescents and young adults still have the...
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Dimensions of the anterior cruciate ligament and thickness of the distal femoral growth plate in children: a MRI-based study
BackgroundWhen determining the dimensions of an anterior cruciate ligament (ACL) graft in children, bone age should be considered in addition to the...
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A randomized pilot study to evaluate graft versus fistula vascular access strategy in older patients with advanced kidney disease: results of a feasibility study
BackgroundAlthough older adults encompass almost half of patients with advanced chronic kidney disease, it remains unclear which long-term...
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Closure of small skull base defects with muscle plug napkin ring technique: how I do it
BackgroundDefects through the skull base into the paranasal sinuses can occur during anterior skull base procedures, risking cerebrospinal fluid leak...
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The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of antibody functions. The composition of the IgG glycome is...
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Off-the-shelf CAR-T cell therapies for relapsed or refractory B-cell malignancies: latest update from ASH 2023 annual meeting
Currently, many off-the-shelf chimeric antigen receptor (CAR)-T cell products are under investigation for the treatment of relapsed or refractory...
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Anterior cruciate ligament grafts display differential maturation patterns on magnetic resonance imaging following reconstruction: a systematic review
PurposeThe appearance of anterior cruciate ligament (ACL) grafts on magnetic resonance imaging (MRI) is related to graft maturity and mechanical...
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Current progress of CAR-T-cell therapy for patients with multiple myeloma
Currently available chimeric antigen receptor (CAR)-engineered T-cell therapies targeting B-cell maturation antigen (BCMA), namely, idecabtagene...
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Fatal BK polyomavirus-associated pneumonia: report of two cases with literature review
BackgroundIn immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK...
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Chitosan 3D scaffolds with resolvin D1 for vertebral arthrodesis: a pilot study
PurposeOver the last years, the number of vertebral arthrodesis has been steadily increasing. The use of iliac crest bone autograft remains the “gold...
