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Association of leptin–melanocortin gene polymorphisms with the risk of obesity in northwest Indian population
BackgroundObesity, a multifaceted endocrine issue, is adversely affecting all age groups and is posing a significant public health challenge. The...
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Association of BMAL1 clock gene polymorphisms with fasting glucose in children
BackgroundThe brain and muscle Arnt-like protein-1 ( BMAL1 ) gene is an important circadian clock gene and previous studies have found that certain...
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Decoding the interaction between miR-19a and CBX7 focusing on the implications for tumor suppression in cancer therapy
Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth, genetic alterations, and disruption of normal cellular...
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Association of MLL3 and TGF-β signaling gene polymorphisms with the susceptibility and prognostic outcomes of Stanford type B aortic dissection
ObjectiveThis study aims to investigate the association of lysine methyltransferase 2 C (MLL3) and transforming growth factor β (TGF-β)...
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Gene expression networks regulated by human personality
Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to...
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Association analysis of SOCS3, JAK2 and STAT3 gene polymorphisms and genetic susceptibility to type 2 diabetes mellitus in Chinese population
AimThe association of polymorphisms in the three genes of SOCS3, JAK2 and STAT3 with genetic susceptibility to type 2 diabetes mellitus (T2DM) was...
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The interaction of early life factors and depression-associated loci affecting the age at onset of the depression
Multiple previous studies explored the associations between early life factors and the age at onset of the depression. However, they only focused on...
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Prenatal exposure to multiple environmental chemicals and birth size
BackgroundEpidemiological studies addressing the combined effects of exposure to chemical mixtures at different stages of pregnancy on birth size are...
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ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population
Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as...
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Impact of Environmental Exposures on Lung Cancer in Patients Who Never Smoked
BackgroundDespite the rising incidence of lung cancer in patients who never smoked, environmental risk factors such as ambient air pollution in this...
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Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model
BackgroundIndustrial progress has led to the omnipresence of chemicals in the environment of the general population, including reproductive-aged and...
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Autoinflammatory gene mutations associated with eosinophilia and asthma
BackgroundRespiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with...
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Relationship Between TIMP-2 and TIMP-3 Gene Variants and Breast Cancer Risk in an Iranian Population
BackgroundsTissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of active MMPs. TIMP-2 and TIMP-3 are cell cycle regulatory...
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Novel splicing variant and gonadal mosaicism in DYRK1A gene identified by whole-genome sequencing in multiplex autism spectrum disorder families
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with considerable genetic heterogeneity. The disorder is clinically...
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Environmental and life-style risk factors for esophageal squamous cell carcinoma in Africa: a systematic review and meta-analysis
BackgroundThe African Esophageal Squamous Cell Carcinoma (ESCC) corridor, which spans from Ethiopia down to South Africa, is an esophageal cancer...
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Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD)
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder that results from the interaction of both genetic...
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The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review
BackgroundGiven the inconsistencies in current studies regarding the impact of FKBP5 gene polymorphisms on depression, arising from variations in...
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Nature with Nurture: the Role of Intrinsic Genetic and Extrinsic Environmental Factors on Eosinophilic Esophagitis
Purpose of ReviewAs the rising prevalence and incidence of eosinophilic esophagitis (EoE) has quickly outpaced the rate of esophageal biopsies,...
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Associations of socioeconomic status with infectious diseases mediated by lifestyle, environmental pollution and chronic comorbidities: a comprehensive evaluation based on UK Biobank
BackgroundSocioeconomic status (SES) inequity was recognized as a driver of some certain infectious diseases. However, few studies evaluated the...
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PROX1 gene rs340874 single nucleotide polymorphism, body mass index, and early atherosclerosis in Chinese individuals: the CRC study
BackgroundAtherosclerosis is a primary risk factor for cardiovascular disease, but its pathogenesis is unclear. Previous studies reported that the...
