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The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis
Patent ductus arteriosus (PDA), one of the most common disorders in newborns, is associated with many complications in premature infants such as...
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Current and future antiplatelet therapies: emphasis on preserving haemostasis
Antiplatelet drugs, such as aspirin, P2Y 12 antagonists, and glycoprotein (GP) IIb/IIIa inhibitors, have proved to be successful in reducing the...
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The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis
The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial interaction with subendothelial von Willebrand factor (VWF)...
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Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
Abivertinib, a third-generation tyrosine kinase inhibitor, is originally designed to target epidermal growth factor receptor (EGFR)-activating...
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Toward Brief Dual Antiplatelet Therapy and P2Y12 Inhibitors for Monotherapy After PCI
The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention remains a controversial topic. The European Society...
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Outcome of CentriMag™ extracorporeal mechanical circulatory support use in critical cardiogenic shock (INTERMACS 1) patients
PurposePrognosis of patients presenting with INTERMACS 1 critical cardiogenic shock is generally poor. The aim of our study was to investigate the...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
BackgroundThe global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching...
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Bleeding avoidance strategies in percutaneous coronary intervention
For many years, bleeding has been perceived as an unavoidable consequence of strategies aimed at reducing thrombotic complications in patients...
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Platelet biology and functions: new concepts and clinical perspectives
Platelets — blood cells continuously produced from megakaryocytes mainly in the bone marrow — are implicated not only in haemostasis and arterial...
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Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by innate immunity, is one of the primary causes of early...
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Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane....
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Patient Blood Management in Adult Extracorporeal Membrane Oxygenation Patients
Purpose of ReviewThis narrative review provides a framework for contemporary patient blood management (PBM) in adult extracorporeal membrane...
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Immune cell behaviour and dynamics in the kidney — insights from in vivo imaging
The actions of immune cells within the kidney are of fundamental importance in kidney homeostasis and disease. In disease settings such as acute...
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Antiplatelet mechanism of an herbal mixture prepared from the extracts of Phyllostachys pubescens leaves and Prunus mume fruits
BackgroundBamboo ( Phyllostachys pubescens ) leaves and Japanese apricot ( Mume fructus ) fruit are traditionally recognized to be safe herbs broadly...
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Targeting BTK in CLL: Beyond Ibrutinib
Purpose of ReviewWhile the Bruton’s tyrosine kinase inhibitor (BTKi) ibrutinib has revolutionized the treatment of chronic lymphocytic leukemia...
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Inflammation in Coronary Atherosclerosis and Its Therapeutic Implications
Atherosclerotic coronary artery disease has a complex pathogenesis which extends beyond cholesterol intimal infiltration. It involves chronic...
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Current Understanding of Vascular Wall Pathophysiology in Erectile Dysfunction and Priapism
The contents of irregularities in the physiology of the vascular wall have been closely associated with erectile dysfunction. Understanding the...
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Complexity of Antiplatelet Therapy in Coronary Artery Disease Patients
Patients with coronary artery disease (CAD) presenting with acute coronary syndrome or undergoing coronary stenting are indicated to treatment with...
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Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action
PurposePlatelet-rich plasma (PRP) therapy has been used as an adjunct to fertility treatments in women with very low ovarian reserve and premature...
