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Multiple machine-learning tools identifying prognostic biomarkers for acute Myeloid Leukemia
BackgroundAcute Myeloid Leukemia (AML) generally has a relatively low survival rate after treatment. There is an urgent need to find new biomarkers...
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Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation
BackgroundTraditional Chinese medicine has been used for a long time to treat a variety of gynecological diseases. Among various traditional Chinese...
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Evaluating the effects of curcumin nano-chitosan on miR-221 and miR-222 expression and Wnt/β-catenin pathways in MCF-7, MDA-MB-231 and SKBR3 cell lines
BackgroundBreast cancer is one of the most common diseases worldwide that affects women of reproductive age. miR-221 and miR-222 are two highly...
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Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules
BackgroundObesity associated type 2 diabetes mellitus is a metabolic disorder ; however, the etiology of obesity associated type 2 diabetes mellitus...
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Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis
ObjectiveTo identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS)...
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Identification of hub genes related to the progression of type 1 diabetes by computational analysis
BackgroundType 1 diabetes (T1D) is a serious threat to childhood life and has fairly complicated pathogenesis. Profound attempts have been made to...
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Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal–fetal interface
BackgroundDecidual macrophages participate in immune regulation at the maternal–fetal interface. Abnormal M1/M2 polarization of decidual macrophages...
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Epigenetics, cryptorchidism, and infertility
BackgroundCryptorchid boys with defective mini-puberty and impaired differentiation of Ad spermatogonia (high infertility risk) have altered...
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Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome
The epididymal function and gene expression in mammals are under the control of the testis. Sex steroids are secreted from the testis and act on the...
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A study on the anti-osteoporosis mechanism of isopsoralen based on network pharmacology and molecular experiments
ObjectiveOsteoporosis (OP) is a disease caused by multiple factors. Studies have pointed out that isopsoralen (IPRN) is one of the most effective...
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A diagnostic model based on bioinformatics and machine learning to differentiate bipolar disorder from schizophrenia and major depressive disorder
Bipolar disorder (BD) showed the highest suicide rate of all psychiatric disorders, and its underlying causative genes and effective treatments...
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GEMIN4, a potential therapeutic targets for patients with basal-like subtype breast cancer
BackgroundBasal-like breast cancer (BLBC) takes up about 10–20% of all breast cancer(BC), what’s more, BLBC has the lowest survival rate among all BC...
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zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma
PurposeKidney clear cell carcinoma (KIRC) has a poor prognosis, high morbidity and mortality rates, and high invasion and metastasis rate, and...
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Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer
BackgroundTriple Negative Breast Cancer (TNBC) is a particular type of breast cancer with the highest mortality rate. Essential oils are concerned...
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Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice
BackgroundQuiescin sulfhydryl oxidase 2 (QSOX2) is a flavin adenine dinucleotide-dependent sulfhydryl oxidase that is known to be involved in protein...
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Nonlinear relationship between chromatin accessibility and estradiol-regulated gene expression
Chromatin accessibility is central to basal and inducible gene expression. Through ATAC-seq experiments in estrogen receptor-positive (ER+) breast...
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Comparison of gene expression between human and mouse iPSC-derived cardiomyocytes for stem cell therapies of cardiovascular defects via bioinformatic analysis
BackgroundPreclinical studies have demonstrated the potential use of induced pluripotent stem cells (iPSCs) to treat cardiovascular disease (CVD). In...
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Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation
The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and...
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Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
Synaptic potentiation underlies various forms of behavior and depends on modulation by multiple activity-dependent transcription factors to...
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Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach
BackgroundInterstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin is a naturally occurring...
