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A Review of Calcitonin Gene-Related Peptide and Its Implications for Vestibular Disorders
Purpose of reviewCalcitonin gene-related peptide (CGRP) is an inflammatory neuropeptide widely present throughout the body and involved in many...
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The ultimate guide to the anti-CGRP monoclonal antibodies galaxy
BackgroundAnti-CGRP monoclonal antibodies have represented a real revolution in the field of headaches, being the result of an extraordinary process...
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Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review
BackgroundMany patients with chronic migraine do not achieve clinically meaningful improvement in their headache frequency with monotherapy. The...
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Management of medication overuse (MO) and medication overuse headache (MOH) S1 guideline
IntroductionChronic headache due to the overuse of medication for the treatment of migraine attacks has a prevalence of 0.5–2.0%. This guideline...
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CGRP Targeting Therapy for Chronic Migraine—Evidence from Clinical Trials and Real-world Studies
Purpose of ReviewMonoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor have become part of the standard treatment for...
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Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
BackgroundCurrent evidence on the safety of calcitonin gene–related peptide antagonists (CGRP-A) in pregnancy for the treatment of both episodic and...
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The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression
BackgroundMigraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment...
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CGRP-Antikörper in der Migräneprophylaxe
Migraine is associated with a high individual level of suffering. Therefore, an effective preventive treatment is highly important. The spectrum of...
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Mode and site of action of therapies targeting CGRP signaling
Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs...
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Methodological considerations on real-world evidence studies of monoclonal antibodies against the CGRP-pathway for migraine: a systematic review
BackgroundReal-world data are accumulating on the effectiveness, tolerability and safety of anti-calcitonin gene-related peptide pathway monoclonal...
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CGRP-Targeted Therapy for Episodic and Chronic Cluster Headache
Purpose of ReviewChronic cluster headache (CH) substantially affects patients’ quality of life, and treatment remains challenging. The current...
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Cardiovascular Disease and Migraine: Are the New Treatments Safe?
Purpose of ReviewThe authors present data on cardiovascular safety for the new acute and preventive migraine treatments including ditans, gepants,...
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Unmet Needs in Preventive Treatment of Migraine
Migraine represents the most common cause of work disability in young women and the second one in the general population. Preventive treatment can...
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