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Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes
The serotonergic system in the human brain modulates several physiological processes, and altered serotonergic neurotransmission has been implicated...
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Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients
Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models of psychiatric disorders that account for a...
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Sheep embryonic stem-like cells engrafted into sheep femoral condyle osteochondral defects: 4-year follow-up
BackgroundArticular cartilage lacks a regenerative response. Embryonic stem cells (ESCs) are a source of pluripotent cells for cartilage...
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Three-dimensional modeling of human neurodegeneration: brain organoids coming of age
The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in aging nations. These relentless and progressive diseases...
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Advances in stem cell research for the treatment of primary hypogonadism
In Leydig cell dysfunction, cells respond weakly to stimulation by pituitary luteinizing hormone, and, therefore, produce less testosterone, leading...
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Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally...
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Metabolic Regulation of Human Pluripotent Stem Cell-Derived Cardiomyocyte Maturation
Purpose of ReviewThis review summarizes the important role that metabolism plays in driving maturation of human pluripotent stem cell-derived...
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Modeling Psychiatric Disorder Biology with Stem Cells
Purpose of ReviewWe review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and...
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Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction
BackgroundCOVID-19 is a pandemic respiratory and vascular disease caused by SARS-CoV-2 virus. There is a growing number of sensory deficits...
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All roads lead to Rome: the many ways to pluripotency
Cell pluripotency, spatial restriction, and development are spatially and temporally controlled by epigenetic regulatory mechanisms that occur...
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Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules
BackgroundMotor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases or spinal cord injuries....
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The Role of TGF—β Signaling in Cardiomyocyte Proliferation
Purpose of ReviewThe loss of contractile function after heart injury remains one of the major healthcare issues of our time. One strategy to deal...
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IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission
Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual...
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Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly...
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Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly
Human induced pluripotent stem cells (hiPSCs) have revolutionized the generation of experimental disease models, but the development of protocols for...
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miR-484 suppresses endocrine therapy-resistant cells by inhibiting KLF4-induced cancer stem cells in estrogen receptor-positive cancers
Endocrine therapy (mainly anti-estrogen therapy) is the mainstay of treatment for estrogen receptor (ER) positive breast cancer (BCa). However,...
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Decellularized extracellular matrix mediates tissue construction and regeneration
Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D)...
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A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties
BackgroundCancer stem cells (CSCs) are considered as the major cause to tumor initiation, recurrence, metastasis, and drug resistance, driving poor...
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Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas
Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered...
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Effect of a Small Physiological Electric Field on Angiogenic Activity in First-Trimester Extravillous Trophoblast Cells
Electrical stimulation induces significant angiogenesis in vivo. We have shown that electrical stimulation of trophoblast cells has important...