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Cellular and mitochondrial mechanisms of atrial fibrillation
The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific...
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Dnali1 is required for sperm motility and male fertility in mice
BackgroundThe sperm flagellum is an evolutionarily conserved specialized organelle responsible for sperm motility and male fertility. Deleterious...
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Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response
Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The develo** adolescent brain is highly sensitive to...
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Approach to Congenital Diarrhea and Enteropathies (CODEs)
Congenital diarrhea and enteropathies (CODEs) constitute a group of rare genetic disorders characterized by severe diarrhea and malabsorption in the...
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Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead...
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The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in the circulation but also...
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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
Owing to the increasing incidence and prevalence of inflammatory bowel disease (IBD) worldwide, effective and safe treatments for IBD are urgently...
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Enhancing radiosensitivity in triple-negative breast cancer through targeting ELOB
Enhancing radiotherapy sensitivity is crucial for improving treatment outcomes in triple-negative breast cancer (TNBC) patients. In this study, we...
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A machine learning-based model for a dose point kernel calculation
PurposeAbsorbed dose calculation by kernel convolution requires the prior determination of dose point kernels (DPK). This study reports on the...
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Mitochondrial dysfunction induced by bedaquiline as an anti-Toxoplasma alternative
Toxoplasma gondii is a zoonotic parasite that infects one-third of the world’s population and nearly all warm-blooded animals. Due to the complexity...
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Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted...
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NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function
Aims/hypothesisAll forms of diabetes result from insufficient functional beta cell mass. Due to the relatively limited expression of several...
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AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism
Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for...
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SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy
Pancreatic cancer is one of the deadliest forms of cancer, which is attributed to lack of effective treatment options and drug resistance....
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Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor...
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Ischemia time impacts on respiratory chain functions and Ca2+-handling of cardiac subsarcolemmal mitochondria subjected to ischemia reperfusion injury
BackgroundMitochondrial impairment can result from myocardial ischemia reperfusion injury (IR). Despite cardioplegic arrest, IR-associated...
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UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma
The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. The first targeted therapy,...
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Mesenchymal stem cells (MSCs) in Leber’s hereditary optic neuropathy (LHON): a potential therapeutic approach for future
BackgroundOptic neuropathy has become a new typical syndromic multi-system disease that leads to optic atrophy. This review discusses potential...
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Intrinsic differences in rod and cone membrane composition: implications for cone degeneration
PurposeIn many retinal pathological conditions, rod and cone degeneration differs. For example, the early-onset maculopathy Stargardts disease type 1...
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A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients: case report and functional studies
BackgroundMT-ATP6 is a mitochondrial gene which encodes for the intramembrane subunit 6 (or A) of the mitochondrial ATP synthase, also known asl...
