Search
Search Results
-
Effects of Kami Guibi-tang in patients with mild cognitive impairment: study protocol for a phase III, randomized, double-blind, and placebo-controlled trial
BackgroundAmnestic mild cognitive impairment (aMCI) is often considered a precursor to Alzheimer’s disease (AD) and represents a key therapeutic...
-
Double Impact: A Dyadic Discrimination Model for Poor, Minority, and Pregnant Couples
Frequent daily discrimination compounds the negative health impacts of those with multiple marginalized identities, including pregnant mothers and...
-
Effects of transcranial direct current stimulation on patients with post-stroke fatigue: a study protocol for a double-blind randomized controlled trial
IntroductionPost-stroke fatigue (PSF) is an abnormal, persistent, and unexplained physical and psychological tiredness in patients after stroke. It...
-
The trochanteric double contour is a valuable landmark for assessing femoral offset underestimation on standard radiographs: a retrospective study
BackgroundInaccurate projection on standard pelvic radiographs leads to the underestimation of femoral offset—a critical determinant of postoperative...
-
Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial
BackgroundAlfaxalone is a fast acting intravenous anaesthetic with high therapeutic index. It is an analogue of the naturally-occurring neurosteroid...
-
Study protocol for a phase 1/2, single-centre, double-blind, double-dummy, randomized, active-controlled, age de-escalation trial to assess the safety, tolerability and immunogenicity of a measles and rubella vaccine delivered by a microneedle patch in healthy adults (18 to 40 years), measles and rubella vaccine-primed toddlers (15 to 18 months) and measles and rubella vaccine-naïve infants (9 to 10 months) in The Gambia [Measles and Rubella Vaccine Microneedle Patch Phase 1/2 Age De-escalation Trial]
BackgroundNew strategies to increase measles and rubella vaccine coverage, particularly in low- and middle-income countries, are needed if...
-
The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial
BackgroundThe ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment...
-
Brain‐oscillation-synchronized stimulation to enhance motor recovery in early subacute stroke: a randomized controlled double‐blind three‐ arm parallel‐group exploratory trial comparing personalized, non‐ personalized and sham repetitive transcranial magnetic stimulation (Acronym: BOSS-STROKE)
BackgroundStroke is a major cause of death and the most frequent cause of permanent disability in western countries. Repetitive transcranial brain...
-
Efficacy of mHealth and education-led peer counseling for patients with hypertension and coronary artery disease in Pakistan: study protocol for a double-blinded pragmatic randomized-controlled trial with factorial design
BackgroundHypertension is a highly relevant public health challenge. Digital interventions may support improving adherence to anti-hypertensive...
-
Favipiravir and/or nitazoxanide: a randomized, double-blind, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)
BackgroundThe 2020 pandemic of SARS-CoV-2 causing COVID-19 disease is an unprecedented global emergency. COVID-19 appears to be a disease with an...
-
Reader bias in breast cancer screening related to cancer prevalence and artificial intelligence decision support—a reader study
ObjectivesThe aim of our study was to examine how breast radiologists would be affected by high cancer prevalence and the use of artificial...
-
Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial
BackgroundWhereas lowering the intraocular pressure (IOP) can slow optic nerve degeneration in glaucoma, many patients with glaucoma continue to...
-
Assessing the Impact of Structured Reports for Fluoroscopic Double-Contrast Barium Esophagrams
Fluoroscopic barium swallow examinations are a commonly performed radiologic study in the evaluation of dysphagia. These studies remain essential in...
-
Transfer of FRozen Encapsulated multi-donor Stool filtrate for active ulcerative Colitis (FRESCO): study protocol for a prospective, multicenter, double-blind, randomized, controlled trial
BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease with significant morbidity and mortality. Although the precise cause...
-
Is there any added value to substitute the 2D digital MLO projection for a MLO tomosynthesis projection and its synthetic view when a 2D standard digital mammography is used in a one-stop-shop immediate reading mammography screening?
ObjectivesBreast cancer screening consists of batch interpretation of two-view (cranio-caudal CC- and medio-lateral oblique MLO) digital mammography...
-
Artificial Intelligence for Otosclerosis Detection: A Pilot Study
The gold standard for otosclerosis diagnosis, aside from surgery, is high-resolution temporal bone computed tomography (TBCT), but it can be...
-
Effect of MDMA-assisted therapy on mood and anxiety symptoms in advanced-stage cancer (EMMAC): study protocol for a double-blind, randomised controlled trial
BackgroundSymptoms of anxiety and depression are common in patients with terminal illness and multiple challenges exist with timely and effective...
-
Can bag-valve mask ventilation with positive end-expiratory pressure reduce hypoxia during intubation? A prospective, randomized, double-blind trial
BackgroundHypoxia is one of the life-threatening complications of endotracheal intubation. Supplemental oxygen and ventilation play a vital role in...
-
Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with single dose dexmedetomidine in controlled hypertensive patients: prospective randomized double-blind study
BackgroundLaryngoscopy and endotracheal intubation may be associated with adverse events as hypertension, tachycardia, and increased serum...
