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Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats
Introduction and hypothesisIn women with chronic pelvic pain (CPP), interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis frequently...
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Neuromodulation Techniques in Chronic Refractory Coccydynia: A Narrative Review
Refractory coccydynia is a condition characterized by severe coccygeal pain and poses a challenging management dilemma for clinicians. Advancements...
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The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative
PurposeWe have re-evaluated the anatomical arguments that underlie the division of the spinal visceral outflow into sympathetic and parasympathetic...
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Percutaneous dorsal root ganglion block for treating lumbar compression fracture-related pain
BackgroundThe pain of acute compression fracture in the lumbar spine may be refractory to conservative treatment, and surgery is not an optimal...
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Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model
BackgroundDiclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has analgesic and...
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Proposal of a Route Map for Cervical Spinal Ultrasonography: A Simple and Clear Learning Tool for Beginners
Spinal ultrasonography has increasingly been used to image axial structures from the cervical to sacral region in recent years. In this work, we...
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Activation of the High-Affinity Choline Transporter 1 in the Spinal Cord Relieves Stress-Induced Hyperalgesia
BackgroundThe mechanism underlying irritable bowel syndrome (IBS), a common disease with hyperalgesia, remains elusive. The spinal cholinergic system...
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Hemorrhagic Ligamentum Flavum Cyst Associated with Adjacent Bone Erosion: an Uncommon Subtype of Juxta-Facet Cyst—a Case Presentation
Ligamentum flavum cyst of the lumbar spine has seldom been described. The mechanism of formation of these cysts remains unknown, but it is thought to...
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Trigeminal neuralgia
Trigeminal neuralgia (TN) is a facial pain disorder characterized by intense and paroxysmal pain that profoundly affects quality of life and presents...
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Evidence-Based Treatment of Painful Diabetic Neuropathy: a Systematic Review
Purpose of ReviewPainful diabetic neuropathy (PDN) manifests with pain typically in the distal lower extremities and can be challenging to treat. The...
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Role of GRPR in Acupuncture Intervention in the “Itch-scratch Vicious Cycle” Spinal Circuit of Chronic Pruritus
Many previous studies have shown the potential antipruritic effect of acupuncture. This paper reviews the antipruritic mechanisms of acupuncture...
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Diagnostic accuracy of imaging studies for diagnosing root avulsions in post-traumatic upper brachial plexus traction injuries in adults
BackgroundThere is no consensus about which type of imaging study, computed tomography myelography (CTM) or magnetic resonance imaging (MRI),...
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Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review
Purpose of ReviewDespite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of...
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What comprises the plate-like structure between the pancreatic head and the celiac trunk and superior mesenteric artery? A proposal for the term “P–A ligament” based on anatomical findings
A plate-like structure is located posterior to the portal vein system, between the pancreatic head and roots and/or branches of two major arteries of...
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Posterolateral epidural supra-C2-root approach (PESCA) for biopsy of lesions of the odontoid process in same sitting after occipitocervical fixation and decompression—perioperative management and how to avoid vertebral artery injury
This study aims to describe the posterolateral epidural supra-C2-root approach (PESCA), which might be a good alternative to the transoral,...
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Light Therapy in Chronic Migraine
Purpose of ReviewThis review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging...
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Status of peripheral sodium channel blockers for non-addictive pain treatment
The effective and safe treatment of pain is an unmet health-care need. Current medications used for pain management are often only partially...
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Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia
The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory...
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Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy
PurposeTo investigate the AMPK pathway–mediated effect of alpha-lipoic acid (ALA) on the dorsal root ganglia (DRGs) of rats with diabetic peripheral...
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Managing acute phantom limb pain with transcutaneous electrical nerve stimulation: a case report
IntroductionPhantom limb pain is characterized by painful sensations in the amputated limb. The clinical presentation of acute phantom limb pain may...
