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An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis
Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the...
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Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation...
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Clonal dominance is an adverse prognostic factor in acute myeloid leukemia treated with intensive chemotherapy
Intra-tumor heterogeneity portends poor outcome in many cancers. In AML, a higher number of drivers worsens prognosis. The Shannon Index is a robust...
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TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma
Microphthalmia-associated transcription factor (MiT) family aberration-associated renal cell carcinoma (MiTF-RCC) is a subtype of renal cell...
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Deciphering the role of Wnt signaling in acute myeloid leukemia prognosis: how alterations in DNA methylation come into play in patients’ prognosis
Acute myeloid leukemia (AML) is a malignant clonal disorder affecting myeloid differentiation through mechanisms that include epigenetic...
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De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report
BackgroundApproximately 30% of adult acute myeloid leukemia (AML) acquire within fms-like tyrosine kinase 3 gene ( FLT3 ) internal tandem duplications...
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Prognostic and therapeutic implications of measurable residual disease in acute myeloid leukemia
Quantification of measurable residual disease (MRD) provides critical prognostic information in acute myeloid leukemia (AML). A variety of platforms...
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Mutations of epigenetic modifier genes predict poor outcome in adult acute lymphoblastic leukemia
Epigenetic modifier (EM) genes play important roles in the occurrence and progression of acute lymphoblastic leukemia (ALL). However, the prognostic...
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Targeted NGS on sequential bone marrow biopsies aids in the evaluation of cytopenias and monocytosis and documents clonal evolution—a proof of principle study
Differential diagnosis of clonal versus reactive cytopenia and monocytosis, respectively, frequently presents a diagnostic challenge. With the two...
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Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells
BackgroundThe evasion of apoptosis through dysregulated Bcl-2 family members is a hallmark of leukaemia stem cells (LSCs) in acute myeloid leukaemia...
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4-Hydroxyphenyl Retinamide Preferentially Targets FLT3 Mutated Acute Myeloid Leukemia via ROS Induction and NF-κB Inhibition
FMS-like tyrosine kinase 3 (FLT3) mutation is strongly associated with poor prognosis in acute myeloid leukemia (AML). Though many FLT3 inhibitors...
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Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy
Purpose of ReviewAcute myeloid leukemia (AML) in children remains a challenging disease to cure with suboptimal outcomes particularly when compared...
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miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for the...
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Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
Hematologic malignancies are one of the most common cancers, and the incidence has been rising in recent decades. The clinical and molecular features...
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SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia
BackgroundAberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit...
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Prognostic value of CIP2A gene expression in adult Egyptian acute myeloid leukemia patients
BackgroundProtein phosphatase 2A ( PP2A ) functions as a tumor suppressor in many cancers. Cancerous inhibitor of protein phosphatase 2A ( CIP2A )...
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Prognostic significance of DNMT3a gene expression and reactive nitrogen species in newly diagnosed Egyptian de novo adult acute myeloid leukemia patients
BackgroundDNA methyltransferase 3a ( DNMT3a ) gene is a frequently dysregulated epigenetic modifier gene involved in the process of carcinogenesis....
