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Left colonic localization, non-granular morphology, and pit pattern independently predict submucosal fibrosis of naïve colorectal neoplasms before endoscopic submucosal dissection
BackgroundEndoscopic submucosal dissection (ESD) represents the method of choice for removal of large colorectal neoplasms with suspected submucosal...
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Characteristics of synchronous and metachronous duodenal tumors and association with colorectal cancer: a supplementary analysis
BackgroundWe previously reported outcomes of endoscopic resection for duodenal tumors in a large cohort. This study investigated the frequency and...
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Is Metformin Associated with a Lower Prevalence of Polyps, Adenomas, and Colorectal Carcinoma in Patients with Diabetes Mellitus?
PurposeRecent studies suggested a protective role of metformin in the development of colorectal cancer (CRC) and its precursors. We aimed to...
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Gliclazide Reduces Colitis-Associated Colorectal Cancer Formation by Deceasing Colonic Inflammation and Regulating AMPK-NF-κB Signaling Pathway
BackgroundGliclazide is a potential anti-cancer drug candidate for preventing carcinogenesis. However, the effect of gliclazide on colitis-associated...
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Young-onset colorectal cancer
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset...
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Immune checkpoint blockade therapy for BRAF mutant metastatic colorectal cancer: the efficacy, new strategies, and potential biomarkers
BRAF mutant metastatic colorectal cancer has long been considered a tumor with a poor prognosis and a poor response to chemotherapy. Despite the...
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Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study
BackgroundColorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a...
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A novel AI device for real-time optical characterization of colorectal polyps
Accurate in-vivo optical characterization of colorectal polyps is key to select the optimal treatment regimen during colonoscopy. However, reported...
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Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection
PurposeWe sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical...
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Optimal Strategies for Colorectal Cancer Screening
Colorectal cancer (CRC) imposes significant morbidity and mortality, yet it is also largely preventable with evidence-based screening strategies. In...
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A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion
BackgroundIt is important to accurately diagnose the depth of colorectal neoplasia invasion. We aimed to evaluate the usefulness of a new...
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Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake
BackgroundTo validate the feasibility of water enema PET/CT (WE-PET/CT) in incidental colorectal 18 F-FDG uptake and improve the accuracy of...
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Altered gut microbiome composition by appendectomy contributes to colorectal cancer
Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk...
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The pattern-based interpretation of p53 immunohistochemical expression as a surrogate marker for TP53 mutations in colorectal cancer
Mutations in the TP53 gene, most commonly observed in colorectal cancer (CRC), play an essential role in colorectal carcinogenesis. Although p53...
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NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer
BackgroundColorectal cancer (CRC) ranks third in cancer incidence globally and is the second leading cause of cancer-related mortality. The...
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Retrospective study on the feasibility and safety of laparoscopic surgery for complicated fistulizing diverticular disease in a high-volume colorectal center
BackgroundWe assessed feasibility and safety of laparoscopic sigmoidectomy for complicated fistulizing diverticular disease in a tertiary care...
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Artificial intelligence (AI) real-time detection vs. routine colonoscopy for colorectal neoplasia: a meta-analysis and trial sequential analysis
Goals and backgroundStudies analyzing artificial intelligence (AI) in colonoscopies have reported improvements in detecting colorectal cancer (CRC)...
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Comprehensive Analysis of microRNA Expression During the Progression of Colorectal Tumors
BackgroundNo effective early diagnostic biomarkers are available for colorectal cancer (CRC). Therefore, we sought to identify new biomarkers that...
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Selective COX-2 inhibitors do not increase gastrointestinal reactions after colorectal cancer surgery: a systematic review and meta-analysis
BackgroundThe effectiveness of selective COX-2 inhibitors in preventing colorectal cancer recurrence has been demonstrated, however it is unknown how...
