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Real-World Safety and Clinical Outcomes of Macitentan in Asian Patients with Pulmonary Arterial Hypertension: A Prospective Multicenter Study
Background and ObjectiveMacitentan is approved for treating pulmonary arterial hypertension. However, the real-world evidence of macitentan use is...
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Combined physical training protects the left ventricle from structural and functional damages in experimental pulmonary arterial hypertension
BackgroundUnder the adverse remodeling of the right ventricle and interventricular septum in pulmonary arterial hypertension (PAH) the left ventricle...
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Association of non-insulin-based insulin resistance indices with disease severity and adverse outcome in idiopathic pulmonary arterial hypertension: a multi-center cohort study
BackgroundInsulin resistance (IR) plays an important role in the pathophysiology of cardiovascular disease. Recent studies have shown that diabetes...
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Identification of potential susceptibility genes in patients with primary Sjögren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing
BackgroundPulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren’s syndrome (pSS). Several genes have proven to be...
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Retrospective cohort study of pulmonary arterial hypertension associated with connective tissue disease effect on patients’ prognosis
ObjectiveThe objectives of this study are to clarify clinical characteristics and recognize prognostic factors of CTD-PAH patients.
Methods ...
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The diagnostic performance of CT pulmonary angiography in the detection of chronic thromboembolic pulmonary hypertension—systematic review and meta-analysis
ObjectivesTo examine the diagnostic performance of CT of the pulmonary artery (CTPA) as a potential first-choice imaging modality in patients with...
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Diagnosis and Treatment Patterns of Chronic Thromboembolic Pulmonary Hypertension in Russia, Kazakhstan, Turkey, Lebanon, and Saudi Arabia: A Registry Study
BackgroundPatients with chronic thromboembolic pulmonary hypertension (CTEPH) in countries with limited resources have, to date, been poorly...
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Exercise-induced desaturation during a six-minute walk test is associated with poor clinical outcomes in patients with pulmonary arterial hypertension
BackgroundThe six-minute walk test (6MWT) is an established exercise test for patients with pulmonary arterial hypertension (PAH), affording insight...
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Characterization of pulmonary arterial stiffness using cardiac MRI
Pulmonary arterial stiffness (PAS) is a pathologic hallmark of all types of pulmonary hypertension (PH). Cardiac MRI (CMR), a gold-standard imaging...
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Impact of cancer on the prevalence, management, and outcome of patients with chronic thromboembolic pulmonary hypertension
IntroductionChronic thromboembolic pulmonary hypertension (CTEPH) results from unresolved thrombotic obstruction of the pulmonary vasculature. Cancer...
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The problem of pulmonary arterial hypertension in end-stage renal disease: can peritoneal dialysis be the solution
BackgroundPulmonary arterial hypertension (PAH) in the setting of end-stage renal disease (ESRD) has important prognostic and therapeutic...
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Circulating choline levels are associated with prognoses in patients with pulmonary hypertension: a cohort study
BackgroundsMounting evidences have highlighted the association between metabolites and cardiovascular diseases. Our previous works have demonstrated...
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Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn
ObjectiveTo obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent...
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Clinical characteristics and prognosis in systemic lupus erythematosus-associated pulmonary arterial hypertension based on consensus clustering and risk prediction model
BackgroundPulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). This study aims to explore the...
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Pulmonary arterial hypertension in hereditary hemorrhagic telangiectasia associated with ACVRL1 mutation: a case report
IntroductionHereditary hemorrhagic telangiectasia is an autosomal dominant condition with an estimated prevalence of 1 in 5000. It is characterized...
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Unraveling the Complex Relationship—Atrial Fibrillation and Pulmonary Hypertension
Purpose of ReviewIn this article, we underscore the importance of identifying risk factors and monitoring pulmonary hypertension patients for signs...
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The combination of supervised and unsupervised learning based risk stratification and phenoty** in pulmonary arterial hypertension—a long-term retrospective multicenter trial
BackgroundAccurate risk stratification in pulmonary arterial hypertension (PAH), a devastating cardiopulmonary disease, is essential to guide...
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Hospitalization Among Pulmonary Arterial Hypertension Patients With and Without Connective Tissue Disease Comorbidities Prescribed Oral Selexipag
IntroductionPatients with connective tissue disorders (CTD) and pulmonary arterial hypertension (PAH) have a poorer prognosis than those with other...
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Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically...
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Comparative Treatment Persistence and Adherence to Endothelin Receptor Antagonists Among Patients with Pulmonary Arterial Hypertension in Japan: A Real-World Administrative Claims Database Study
IntroductionReal-world data on the comparative effectiveness of endothelin receptor antagonists (ERAs; macitentan, bosentan, ambrisentan) for...
