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MN1 altered astroblastoma with APC and LRP1B gene mutations: a unique variant in the cervical spine of a pediatric patient
PurposeAstroblastomas (AB) are high-grade neoplasms which typically occur within the cerebral hemisphere. However, given the rarity of this neoplasm...
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High-grade serous ovarian carcinoma with a sertoliform pattern associated with BRCA mutation: a clinicopathological and molecular analysis
Herein, we report a clinicopathological and molecular analysis of a case of tubo-ovarian high-grade serous carcinoma (HGSC) with a sertoliform...
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Correction to: Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing
The original version of this article, unfortunately, contained errors.
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Diagnostic usefulness of SpyGlass in intracholecystic papillary neoplasm with pancreaticobiliary maljunction: a case report and comparison with conventional gallbladder cancer with pancreaticobiliary maljunction
BackgroundIntracholecystic papillary neoplasm (ICPN) is one of the precursors of gallbladder cancer defined in the 2010 World Health Organization...
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Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers
BackgroundUrothelial cancer (UC) and prostate cancer (PCa) are the most common cancers among men with a high ratio of mortality in advanced-stages....
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Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer
ObjectiveEpithelial ovarian cancer (EOC) is a heterogeneous disease with diverse clinicopathological features and behaviors, and its heterogeneity...
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Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature
Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal sinuses, or nasopharynx (sinonasal tract). This study evaluated...
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Fibroma of tendon sheath is defined by a USP6 gene fusion—morphologic and molecular reappraisal of the entity
Fibroma of tendon sheath (FTS) is an uncommon benign myofibroblastic neoplasm that arises in association with tenosynovial tissue. Fusions of the USP6 ...
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SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis
BRAF-driven colorectal cancer is among the poorest prognosis subtypes of colon cancer. Previous studies suggest that BRAF -mutant serrated cancers...
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Oxidative stress-triggered Wnt signaling perturbation characterizes the tip** point of lung adeno-to-squamous transdifferentiation
Lkb1 deficiency confers the Kras -mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation (AST)....
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Molecular targeted drugs, comprehensive classification and preclinical models for the implementation of precision immune oncology in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a complex heterogeneous disease with high morbidity and mortality. Recent progress in molecular targeted drugs...
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Exploring the mechanism of fraxetin against acute myeloid leukemia through cell experiments and network pharmacology
ObjectivePrevious studies have shown that fraxetin has antitumor activity in a variety of tumors, but its role in acute myeloid leukemia (AML)...
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Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea
Erectile dysfunction (ED) incidence is higher in patients with obstructive sleep apnea (OSA). Studies have suggested that ED and OSA may activate...
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MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones
Ossifying fibroma of the craniofacial bones is a fibro-osseous lesion characterized by varied patterns of bone formation in a fibroblastic stroma....
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Investigation of cytotoxic and apoptotic effects of disodium pentaborate decahydrate on ovarian cancer cells and assessment of gene profiling
After revealing the anti-cancer properties of boron, which is included in the category of essential elements for human health by the World Health...
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Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia
Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair...
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Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location
BackgroundIn clinical practice, rectal cancer (RC) is classified according to tumor location. However, RC’s genetic characteristics according to...
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Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification
A subset of testicular sex cord-stromal tumors (SCST), which includes neoplasms with mixed histology, cannot be classified into a specific histologic...
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Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart
Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression,...
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Mutational and transcriptional alterations and clinicopathological factors predict the prognosis of stage I hepatocellular carcinoma
BackgroundThe prognosis of hepatocellular carcinoma (HCC) has been extensively studied. However, the impact on prognosis of stage I HCC has not been...
