Search
Search Results
-
Chromatin-Remodeled State in Lymphoma
Purpose of ReviewEmerging evidence has shown that epigenetic derangements might drive and promote tumorigenesis in various types of malignancies and...
-
Comprehensive characterization of the genetic landscape of familial Hirschsprung’s disease
BackgroundHirschsprung’s disease (HSCR) is one of the most common congenital digestive tract malformations and can cause stubborn constipation or...
-
Deciphering the Prognostic Significance of MYD88 and CD79B Mutations in Diffuse Large B-Cell Lymphoma: Insights into Treatment Outcomes
BackgroundThe clinical and genetic characteristics, as well as treatment outcomes, of diffuse large B-cell lymphoma (DLBCL) patients with different MYD88...
-
Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer’s Disease male mice
Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, Aβ1-42 aggregation and cognitive...
-
Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome
BackgroundRubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported...
-
Characteristics and prognosis of EGFR mutations in small cell lung cancer patients in the NGS era
PurposeTargeted therapy has not been effective for small cell lung cancer (SCLC) patients. Although some studies have reported on EGFR mutations in...
-
Molecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6)
BackgroundThere is growing evidence supporting multidisciplinary molecular tumor boards (MTB) in solid tumors whereas hematologic malignancies remain...
-
Neuroendocrine differentiation distinguishes basaloid variant of lung squamous cell carcinoma
BackgroundNeuroendocrine (NE) differentiation is widely studied in non-small cell lung carcinomas (NSCLC) however, its significance remains unclear...
-
-
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients
Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic...
-
Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor—a case report and review of literature
Histiocytic sarcoma (HS) is a rare aggressive hematologic neoplasm that can be associated with low-grade B cell lymphoma. The development of both...
-
-
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete...
-
Analysis of mutation profiles in extranodal NK/T-cell lymphoma: clinical and prognostic correlations
The molecular pathogenesis of extranodal NK/T-cell lymphoma (NKTCL) remains obscured despite the next-generation sequencing (NGS) studies explored on...
-
Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children
Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in children. The diagnostic hallmark of its two variants...
-
Ocular manifestations of congenital anomalies of the kidney and urinary tract (CAKUT)
Congenital anomalies of the kidney and urinary tract (CAKUT) are among the most common birth defects worldwide and a major cause of kidney failure in...
-
UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
UTX/KDM6A, a histone H3K27 demethylase and a key component of the COMPASS complex, is frequently lost or mutated in cancer; however, its tumor...
-
Altered pathways and targeted therapy in double hit lymphoma
High-grade B-cell lymphoma with translocations involving MYC and BCL2 or BCL6 , usually referred to as double hit lymphoma (DHL), is an aggressive...
