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Role of CGRP pathway polymorphisms in migraine: a systematic review and impact on CGRP mAbs migraine therapy
Backgroundthe interest of clinical reaseach in polymorphisms and epigenetics in migraine has been growing over the years. Due to the new era of...
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CGRP and PACAP-38 play an important role in diagnosing pediatric migraine
BackgroundAn increasing number of studies have suggested that the important role of vasoactive peptides, such as pituitary adenylate...
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CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater
BackgroundCalcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely...
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A Review of Calcitonin Gene-Related Peptide and Its Implications for Vestibular Disorders
Purpose of reviewCalcitonin gene-related peptide (CGRP) is an inflammatory neuropeptide widely present throughout the body and involved in many...
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CGRP antibody therapy in patients with drug resistant migraine and chronic daily headache: a real-world experience
BackgroundCalcitonin gene-related peptide (CGRP) (receptor) antibodies (erenumab, fremanezumab and galcanezumab) are increasingly used in...
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Hormonal influences in migraine — interactions of oestrogen, oxytocin and CGRP
Migraine is ranked as the second highest cause of disability worldwide and the first among women aged 15–49 years. Overall, the incidence of migraine...
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Initial experience with novel CGRP-receptor inhibitor therapy in Migraine in the United Arab Emirates: a retrospective observational study
BackgroundErenumab is a calcitonin gene-related peptide (CGRP)-receptor antibody inhibiting CGRP function. CGRP is prominently involved in the...
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Unmet Needs in the Acute Treatment of Migraine
Migraine represents the most common neurologic disorder, ranking second among the world’s causes of disability [expressed as years lived with...
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Effectiveness of Anti-Calcitonin Gene-Related Peptide Medication in Vestibular Migraine: A Retrospective Cohort Study in an Asian Population
BackgroundMigraine and dizziness often coexist, with vestibular migraine (VM) presenting with vestibular symptoms and headaches. Calcitonin...
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Effectiveness of dual migraine therapy with CGRP inhibitors and onabotulinumtoxinA injections: case series
AimsClinical trials for calcitonin gene-related peptide (CGRP) inhibitors excluded the concomitant use of onabotulinumtoxinA; thus, there is a lack...
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A Brief Review of Gepants
Purpose of ReviewGepants are small molecules that antagonize calcitonin gene-related peptide (CGRP) receptors. Due to their favorable side effect...
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New Migraine Drugs for Older Adults
Migraine is one of the most widespread and burdensome diseases, affecting one in every seven individuals in the world, for an estimated global...
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Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor
BackgroundThe clinical use of calcitonin gene-related peptide receptor (CGRP-R) antagonists and monoclonal antibodies against CGRP and CGRP-R has...
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Gepants — a long way to cure: a narrative review
Calcitonin gene-related peptide (CGRP) is probably the most potent vasodilator in cerebral circulation. Forty years after its discovery, the new...