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Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease
Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating metabolic dysfunction-associated steatotic liver disease...
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Heterogeneity of beta-cell function in subjects with multiple islet autoantibodies in the TEDDY family prevention study - TEFA
BackgroundIndividuals with multiple islet autoantibodies are at increased risk for clinical type 1 diabetes and may proceed gradually from stage to...
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Identification and treatment of persistent small airway dysfunction in paediatric patients with asthma: a retrospective cohort study
BackgroundAsthma is a common respiratory disease. In asthma, the small airways have more intensive inflammation and prominent airway remodelling,...
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A longitudinal evaluation of oxidative stress - mitochondrial dysfunction - ferroptosis genes in anthracycline-induced cardiotoxicity
BackgroundAntineoplastic medications, including doxorubicin, idarubicin, and epirubicin, have been found to adversely affect the heart due to...
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N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease
One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA modification. Especially the extent of m 1 A mRNA methylation...
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β-Thalassemia minor & renal tubular dysfunction: is there any association?
ObjectiveBeta(β)-thalassemia is one of the most common hereditary hematologic disorders. Patients with thalassemia minor (TM) are often asymptomatic...
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Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation
BackgroundResponse to metabolic surgery is heterogeneous and the metabolic states that underpin weight loss and metabolic improvement are still...
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Exploring the causal association between serum metabolites and erectile dysfunction: a bidirectional Mendelian randomisation study
Erectile dysfunction is a common sexual disorder in men. Some studies have found a strong association between some serum metabolites and erectile...
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Liraglutide Protects Against Diastolic Dysfunction and Improves Ventricular Protein Translation
PurposeDiastolic dysfunction is an increasingly common cardiac pathology linked to heart failure with preserved ejection fraction. Previous studies...
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Association of persistent tachycardia with early myocardial dysfunction in children undergoing allogeneic hematopoietic cell transplantation
Cancer survivors who have undergone hematopoietic cell transplantation (HCT) are at risk for myocardial dysfunction. Children who receive allogenic...
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Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Coronary microvascular dysfunction (CMD) is associated with cardiac dysfunction and predictive of cardiac mortality in obesity, especially in...
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Autonomic Dysfunction in the Central Nervous System Hypersomnias
Purposeof ReviewSigns and symptoms of autonomic nervous system (ANS) dysfunction have been reported across all disorders of central nervous system...
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Pancreatic beta cell autophagy is impaired in type 1 diabetes
Aims/hypothesisPancreatic beta cells are subjected to exogenous damaging factors such as proinflammatory cytokines or excess glucose that can cause...
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Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes
Aims/hypothesisDiabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat...
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Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?
The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this...
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Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction
MicroRNA(miR)-143 and miR-145 are mainly expressed in vascular smooth muscle cells. However, the relationship between plasma miR-143 or miR-145...
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Prolyl 4-hydroxylase subunit beta (P4HB) could serve as a prognostic and radiosensitivity biomarker for prostate cancer patients
BackgroundProlyl 4-hydroxylase subunit beta (P4HB) has been reported as a suppressor in ferroptosis. However, no known empirical research has focused...
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Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats
BackgroundTitin phosphorylation contributes to left ventricular (LV) diastolic dysfunction. The independent effects of inflammation on the molecular...
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Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Background and AimsThe triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current...
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Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis
BackgroundAccording to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. L...
