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The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma
In the intricate landscape of the tumor microenvironment, tumor-associated macrophages (TAMs) emerge as a ubiquitous cellular component that...
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New routes to eradicating chronic myelogenous leukemia stem cells by targeting metabolism
Chronic myelogenous leukemia (CML) stem cells are the cellular source of the vast majority of mature CML cells and responsible for relapse of CML...
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Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents
Cholestatic liver disease is a disease that causes liver damage and fibrosis owing to bile stasis. It is represented by primary biliary cholangitis...
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Genetics and mechanisms of thoracic aortic disease
Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation or abnormalities in aortic function, such as loss of...
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Is patient-reported outcome improved by nalfurafine hydrochloride in patients with primary biliary cholangitis and refractory pruritus? A post-marketing, single-arm, prospective study
BackgroundPatients with primary biliary cholangitis (PBC) frequently suffer from pruritus, which can severely impair their health-related quality of...
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Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment
BackgroundCyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated...
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Pruritus – ein weiter Weg von der Neurophysiologie zur Klinik
BackgroundThe mutual exchange of results between basic sciences and clinical research as well as their translation into practice, also with regard to...
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Molecular mechanisms and clinical management of cancer bone metastasis
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and...
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State-of-the-art evidence in the treatment of systemic sclerosis
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement, fibrosis and vasculopathy. Treatment in SSc,...
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Innate immune cells in the pathophysiology of calcific aortic valve disease: lessons to be learned from atherosclerotic cardiovascular disease?
Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed world with currently no effective pharmacological treatment...
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Klinische Shortcuts in der Differenzialdiagnostik von Pruritus
Chronic pruritus is a common and burdensome symptom in medicine. The care of patients with chronic pruritus is very complex not only because of the...
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„Off label use“ in der Palliativmedizin
Palliative care serves to improve the quality of life in patients suffering from incurable diseases. Pharmacotherapy of distressing symptoms plays an...
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Molecular and cellular mechanisms of liver fibrosis and its regression
Chronic liver injury leads to liver inflammation and fibrosis, through which activated myofibroblasts in the liver secrete extracellular matrix...
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Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards mortality. Therapies that aim to induce cell death in...
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Lipoprotein (a): When to Measure and How to Treat?
Purpose of ReviewThe purpose of this article is to review current evidence for lipoprotein (a) (Lp(a)) as a risk factor for multiple cardiovascular...
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Construction and prognostic analysis of miRNA-mRNA regulatory network in liver metastasis from colorectal cancer
BackgroundColorectal cancer (CRC) is one of the most common cancers in the world, and liver metastasis is the leading cause of colorectal...
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Therapeutics for Pruritus in Cholestatic Liver Disease: Many Treatments but Few Cures
Purpose of ReviewPruritus in cholestatic liver disease is commonly encountered and difficult to eradicate. It has a major impact on quality of life...
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Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer
PurposeImmunogenomics and earlier, pioneering studies, particularly by Whiteside and colleagues, have indicated a positive role for B-cells in breast...
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Nasobiliary drainage prior to surgical biliary diversion in progressive familial intrahepatic cholestasis type II
Progressive familial intrahepatic cholestasis (PFIC) can cause intense pruritus that is refractory to medical therapy. Surgical biliary diversion...
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The P2X7 purinergic receptor: a potential therapeutic target for lung cancer
PurposePurinergic P2X7 receptor (P2X7R) is a gated ion channel for which adenosine triphosphate (ATP) is a ligand. Activated P2X7R is widely...
