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Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice
Fibroblast growth factor (FGF) 21 is an endocrine growth factor mainly secreted by the liver in response to a ketogenic diet and alcohol consumption....
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Coexistence of Anti-SRP and Anti-SS-A/Ro Antibodies in Inflammatory Myopathy: Does the Association Occur by Chance? A Case Report
Specific autoantibodies are often reported as occurring in autoimmune diseases, with some autoantibodies believed to be myositis-related. These...
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Hereditary spastic paraplegia
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders which involve the corticospinal tracts and present with distinct...
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Impact and Management of Dysphagia in Inflammatory Myopathies
Purpose of ReviewDysphagia is a common symptom in inflammatory myopathies. This review provides an overview on the epidemiology, clinical impact, and...
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Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
RNA modification has recently become a significant process of gene regulation, and the methyltransferase-like (METTL) family of proteins plays a...
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Discovery and repurposing of artemisinin
Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional...
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A network of core and subtype-specific gene expression programs in myositis
Myositis comprises a heterogeneous group of skeletal muscle disorders which converge on chronic muscle inflammation and weakness. Our understanding...
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PD-1 immunobiology in glomerulonephritis and renal cell carcinoma
BackgroundProgrammed cell death protein (PD)-1 receptors and ligands on immune cells and kidney parenchymal cells help maintain immunological...
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Moving towards a systems-based classification of innate immune-mediated diseases
Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders characterized by recurrent episodes of...
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Line blot immunoassays in idiopathic inflammatory myopathies: retrospective review of diagnostic accuracy and factors predicting true positive results
BackgroundLine blot immunoassays (LIA) for myositis-specific (MSA) and myositis-associated (MAA) autoantibodies have become commercially available....
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Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice
Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to...
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Dietary regulation in health and disease
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated...
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Bruton’s tyrosine kinase Inhibitors and Cardiotoxicity: More Than Just Atrial Fibrillation
Purpose of ReviewThe purpose of this review is to summarize the epidemiology, mechanisms, and management of cardiovascular complications of Bruton’s...
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Essential list of medicinal products for rare diseases: recommendations from the IRDiRC Rare Disease Treatment Access Working Group
BackgroundTreatments are often unavailable for rare disease patients, especially in low-and-middle-income countries. Reasons for this include lack of...
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Novel Genetic Discoveries in Primary Immunodeficiency Disorders
The field of Immunology is one that has undergone great expansion in recent years. With the advent of new diagnostic modalities including a variety...
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Anti-transcriptional intermediary factor 1-γ antibody-positive dermatomyositis induced by nivolumab for lung adenocarcinoma: A case report
Immune checkpoint inhibitors can induce immune-related adverse events (irAEs) in different organs. Dermatomyositis is a rare form of systemic irAE....
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Rituximab-associated hypogammaglobulinemia in autoimmune rheumatic diseases: a single-center retrospective cohort study
B-cell targeted therapies, such as rituximab (RTX), are used widely in autoimmune rheumatic diseases (AIRD). RTX can cause hypogammaglobulinemia and...
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Whole-exome sequencing reveals new potential genes and variants in patients with premature ovarian insufficiency
PurposePremature ovarian insufficiency (POI) is a heterogeneous disorder characterized by the cessation of menstrual cycles before the age of...