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Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation
BackgroundAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for myeloid malignancies such as some acute...
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Sporadic and Familial Acute Myeloid Leukemia with CEBPA Mutations
Purpose of ReviewCCAAT enhancer binding protein A ( CEBPA ) gene mutation is one of the common genetic alterations in acute myeloid leukemia (AML),...
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Multiple machine-learning tools identifying prognostic biomarkers for acute Myeloid Leukemia
BackgroundAcute Myeloid Leukemia (AML) generally has a relatively low survival rate after treatment. There is an urgent need to find new biomarkers...
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Allogeneic stem cell transplantation for patients with acute myeloid leukemia (AML) in second complete remission (CR2) transplanted from unrelated donors with post-transplant cyclophosphamide (PTCy). A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Post-transplant cyclophosphamide (PTCy) is being increasingly used as graft-versus-host disease (GVHD) prophylaxis post allogeneic hematopoietic stem...
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p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway
The full-length p200CUX1 protein encoded by the homology frame CUT-like protein (CUX1) plays an important role in tumors as a pro-oncogene or...
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Develo** Strategies to Improve the Efficacy of CAR-T Therapy for Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a fatal blood malignancy. With the development of immunotherapy, particularly chimeric antigen receptor T cells...
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Should anti-thymocyte globulin be added in post-transplant cyclophosphamide based matched unrelated donor peripheral blood stem cell transplantation for acute myeloid leukemia? A study on behalf of the Acute Leukemia Working Party of the EBMT
In this registry-based study which includes acute myeloid leukemia patients who underwent a matched unrelated donor allogeneic peripheral-blood stem...
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Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5
Acute myeloid leukemia (AML) is the most common hematopoietic malignancy with abnormal lipid metabolism. However, currently available information on...
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Acute myeloid leukemia with rare recurring translocations—an overview of the entities included in the international consensus classification
Two different systems exist for subclassification of acute myeloid leukemia (AML); the World Health Organization (WHO) Classification and the...
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Exploring the mechanism of fraxetin against acute myeloid leukemia through cell experiments and network pharmacology
ObjectivePrevious studies have shown that fraxetin has antitumor activity in a variety of tumors, but its role in acute myeloid leukemia (AML)...
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Prognostic factors and clinical outcomes in patients with relapsed acute leukemia after allogeneic hematopoietic stem cell transplantation
Relapse is a significant barrier to allogeneic hematopoietic stem cell transplantation (allo-HSCT) success. To explore the prognosis of patients who...
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Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia
MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote...
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Update on Small Molecule Targeted Therapies for Acute Myeloid Leukemia
The search for effective therapies for the highly heterogenous disease acute myeloid leukemia (AML) has remained elusive. While cytotoxic therapies...
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Inhibition of PI3K-AKT-mTOR pathway and modulation of histone deacetylase enzymes reduce the growth of acute myeloid leukemia cells
One of the most widespread forms of blood cancer is known as acute myeloid leukemia (AML) which has an incidence of 80% with poor prognosis. Although...
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Flow cytometric measurable residual disease in adult acute myeloid leukemia: a preliminary report from Eastern India
Presence of measurable residual disease (MRD) in acute myeloid leukemia (AML) is considered to be an independent predictor of relapse and poorer...
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Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines
Acute myeloid leukemia is one of the most commonly identified hematological malignancies with poor prognosis. This research was planned to identify...
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Identifying prognostic biomarker related to immune infiltration in acute myeloid leukemia
The immune cells of tumor microenvironment (TME) constitute a vital element of the tumor tissue. There is increasing evidence for their clinical...
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Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myeloid leukemia
Post-transplant cyclophosphamide (PTCy) has emerged as a promising graft-versus-host disease (GvHD) prophylaxis in allogeneic hematopoietic stem cell...
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Survival advantage of treosulfan plus fludarabine (FT14) compared to busulfan plus fludarabine (FB4) in active acute myeloid leukemia post allogeneic transplantation: an analysis from the European Society for Blood and Marrow Transplantation (EBMT) Acute Leukemia Working Party (ALWP)
We compared FT14 (fludarabine 150–160 mg/m 2 , treosulfan 42 g/m 2 ) versus FB4 (fludarabine 150–160 mg/m 2 , busulfan 12.8 mg/kg) in acute myeloid...
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Comparing Arsenic-Containing Qinghuang Powder and Low-Intensity Chemotherapy in Elderly Patients with Acute Myeloid Leukemia
ObjectiveTo compare the clinical effect of arsenic-containing Qinghuang Powder (QHP) and low-intensity chemotherapy (LIC) in treatment of elderly...