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Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice
Long-lasting fear-related disorders depend on the excessive retention of traumatic fear memory. We previously showed that the...
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Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Since more than 3 decades, schizophrenia (SZ) has been regarded as a neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ...
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LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia
Schizophrenia is a complex genetic disorder, the non-Mendelian features of which are likely complicated by epigenetic factors yet to be elucidated....
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Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
Genetic factors significantly affect the pathogenesis of psychiatric disorders. However, the specific pathogenic mechanisms underlying these effects...
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Effects of intranasal insulin as an enhancer of fear extinction: a randomized, double-blind, placebo-controlled experimental study
Fear-extinction based psychotherapy (exposure) is the most effective method for treating anxiety disorders. Notwithstanding, since some patients show...
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Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped case
Myoclonus in the context of COVID-19 is an increasingly recognized condition. The occurrence in an ICU context in hypoxic patients, with metabolic...
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Physiological parameters of mental health predict the emergence of post-traumatic stress symptoms in physicians treating COVID-19 patients
Lack of established knowledge and treatment strategies, and change in work environment, may altogether critically affect the mental health and...
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GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is characterized by the predictable onset of mood and physical symptoms secondary to gonadal steroid...
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D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans
The D-aspartate oxidase ( DDO ) gene encodes the enzyme responsible for the catabolism of D-aspartate, an atypical amino acid enriched in the mammalian...
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Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription
Large-scale genetic screening has identified KMT5B (SUV420H1) , which encodes a histone H4 K20 di- and tri-methyltransferase highly expressed in...
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The role of orphan receptor GPR139 in neuropsychiatric behavior
Orphan G protein Coupled Receptors (GPCRs) present attractive targets both for understanding neuropsychiatric diseases and for development of novel...
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Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life
BackgroundChromodomain helicase DNA-binding protein 8 ( Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 ...
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The impact of sound stimulations during pregnancy on fetal learning: a systematic review
BackgroundThe develo** nervous system in utero is exposed to various stimuli with effects that may be carried forward to the neonatal period. This...
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Sex-dependent role for EPHB2 in brain development and autism-associated behavior
Autism spectrum disorder (ASD) is characterized by impairments in social communication and interaction and restricted, repetitive behaviors. It is...
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Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area
The amygdala, a critical brain region responsible for emotional behavior, is crucially involved in the regulation of the effects of stress on...
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Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse
The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic...
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Effects of Hormonal Contraceptives on Mood: A Focus on Emotion Recognition and Reactivity, Reward Processing, and Stress Response
Purpose of ReviewWe review recent research investigating the relationship of hormonal contraceptives and mood with a focus on relevant underlying...
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The incidence of enlarged vestibular aqueduct among hearing-impaired children: hospital-based tertiary care referral center
BackgroundThe most common radiologically detectable congenital inner ear anomaly is an enlarged vestibular aqueduct (EVA), which is associated with...
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Aberrant ventral dentate gyrus structure and function in trauma susceptible mice
Post-traumatic stress disorder (PTSD) is a psychiatric disorder vulnerable individuals can develop following a traumatic event, whereas others are...
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Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus
Reduced activity of the mediodorsal thalamus (MD) and abnormal functional connectivity of the MD with the prefrontal cortex (PFC) cause cognitive...
