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Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located at close proximity to the colorectal epithelium, the gut...
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Microbiome and Colorectal Cancer
Purpose of ReviewThe trillions of microbes collectively referred to as the human microbiota inhabit the human body and establish a beneficial...
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Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice
Aims/hypothesisAdopting a diet containing indigestible fibre compounds such as prebiotics to fuel advantageous bacteria has proven beneficial for...
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The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression
We previously have identified the ectopic expression of Rac1b, an activated and novel splice variant of Rac1, in a subset of human colorectal...
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Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma,...
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Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions
Colorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA’s...
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Can cannabidiol inhibit angiogenesis in colon cancer?
Colon cancer is the third most common human malignancy and a main cause of death worldwide. The current study was carried out to investigate the...
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Effective chemotherapy of heterogeneous and drug-resistant early colon cancers by intermittent dose schedules: a computer simulation study
PurposeThe effectiveness of cancer chemotherapy is limited by intra-tumor heterogeneity, the emergence of spontaneous and induced drug-resistant...
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Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis
BackgroundThe role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was...
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Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance
Molecular alterations preceding endometrial and ovarian cancer and the sequence of events are unknown. Consecutive specimens from lifelong...
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Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors?
BackgroundPoly(ADP-ribose) polymerases (PARP) are a large family of enzymes involved in several cellular processes, including DNA single-strand break...
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Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer
Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal carcinogenesis. The pathogenic mechanisms of colorectal...
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Flaxseed Bioactive Compounds and Colorectal Cancer Prevention
Purpose of ReviewFlaxseed and its bioactive components have been associated with a decreased risk of colorectal cancer incidence and progression....
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Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice
Mice lacking genes involving in the DNA-damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic challenges....
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Author Correction: Chemoprevention of Colorectal Cancer in High-Risk Patients: from Molecular Targets to Clinical Trials
In the original version of this article, which published in Current Colorectal Cancer Reports , Volume 13, Issue 3, June 2017, the references in both...