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Fueling CARs: metabolic strategies to enhance CAR T-cell therapy
CAR T cells are widely applied for relapsed hematological cancer patients. With six approved cell therapies, for Multiple Myeloma and other B-cell...
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Metabolic reprogramming in the tumor microenvironment of liver cancer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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Isoforms of IDH in breast carcinoma: IDH2 as a potent prognostic factor associated with proliferation in estrogen-receptor positive cases
BackgroundIsocitrate dehydrogenase (IDH) is an important enzyme that oxidatively decarboxylates isocitrate to α-ketoglutarate, and three isoforms...
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Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways
IntroductionThe increase of ATP concentration in the extracellular space represents one of the effective signals that stimulate the physiological...
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Metabolism, metabolites, and macrophages in cancer
Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug...
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Branched-chain amino acids in cardiovascular disease
Research conducted in the past 15 years has yielded crucial insights that are resha** our understanding of the systems physiology of branched-chain...
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Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer
Although the role of isocitrate dehydrogenase (IDH) mutation in promoting cancer development has been well-characterized, the impact of wild-type IDH...
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Rifampicin efficacy against doxorubicin-induced cardiotoxicity in mice
BackgroundThe toxic effect of doxorubicin on the heart limits its clinical usage in cancer therapy. This work intended to investigate, for the first...
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation...
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Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression....
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Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation
PurposeIsocitrate dehydrogenase 1 (IDH1) mutations are associated with improved survival in gliomas. Depending on the IDH1 status, TERT promoter...
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Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2
BackgroundThe adaptation of cellular metabolism is considered a hallmark of cancer. Oncogenic signaling pathways support tumorigenesis and cancer...
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Enchondromatosis and Growth Plate Development
Purpose of reviewEnchondroma is a common cartilage benign tumor that develops from dysregulation of chondrocyte terminal differentiation during...
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Mitochondrial homeostasis: sha** health and disease
Mitochondria serve as the primary site for metabolizing the three major nutrients, underscoring their pivotal role in cellular energy metabolism and...
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Divalproex, Valproate, & Develo** Treatment Options for Cluster Headache Prophylaxis: Clinical Practice Considerations
Regarding the preventive treatment of CH, there are few placebo-controlled studies, meaning most treatment recommendations by physicians are limited...
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Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer
BackgroundEffective treatment for patients with advanced thyroid cancer is lacking. Metabolism reprogramming is required for cancer to undergo...
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A review article of inflammatory bowel disease treatment and pharmacogenomics
Inflammatory bowel disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is...
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Pathological mechanisms and treatment of sporadic Parkinson’s disease: past, present, and future
For a special issue, we review studies on the pathogenesis of nigral cell death and the treatment of sporadic Parkinson’s disease (sPD) over the past...
