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Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance
BackgroundSacituzumab govitecan is an antibody–drug conjugate that delivers SN-38, an active metabolite of irinotecan, to the target molecule,...
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FGF21 modulates hippocampal cold-shock proteins and CA2-subregion proteins in neonatal mice with hypoxia–ischemia
BackgroundFibroblast growth factor 21 (FGF21) is a neuroprotectant with cognitive enhancing effects but with poorly characterized mechanism(s) of...
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Identification of the immune-related biomarkers in Behcet’s disease by plasma proteomic analysis
BackgroundThis study aimed to investigate the expression profile of immune response-related proteins of Behcet’s disease (BD) patients and identify...
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Hypoxia–ischemia-mediated effects on neurodevelopmentally regulated cold-shock proteins in neonatal mice under strict temperature control
BackgroundNeonates have high levels of cold-shock proteins (CSPs) in the normothermic brain for a limited period following birth. Hypoxic–ischemic...
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Relationships of emerging biomarkers of cancer cachexia with quality of life, appetite, and cachexia
PurposeQuality of life (QoL), appetite, cachexia, and biomarkers [albumin, hemoglobin (Hb), neutrophils, lymphocytes, platelets, C-reactive protein...
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Clinical and functional characteristics, possible causes, and impact of chronic cough in patients with cerebellar ataxia, neuropathy, and bilateral vestibular areflexia syndrome (CANVAS)
Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is an hereditary autosomal recessive disease. Recent studies...
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Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer
The hormonal transcription factor androgen receptor (AR) is a master regulator of prostate cancer (PCa). Protein palmitoylation, which attaches a...
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The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
BackgroundUbiquitin/ubiquitin-like (Ub/UBL)-related genes have been reported to be associated with the survival of osteosarcoma patients but have not...
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Emerging markers of cancer cachexia and their relationship to sarcopenia
PurposeEmerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of...
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Lrriq1 is an essential factor for fertility by suppressing apoptosis
PurposeLeucine-rich repeats and IQ motif containing 1 ( LRRIQ1 ) gene is reportedly associated with plasma inhibin B levels. However, the function of LRRIQ1...
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VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration
Activation of innate immunity in the brain is a prominent feature of Alzheimer’s disease (AD). The present study investigated the regulation of...
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Hämoperfusion und Plasmapherese auf der Intensivstation
In addition to kidney replacement procedures, several other extracorporeal procedures are employed in the intensive care unit. Hemoperfusion with...
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Vaginal Bacteria Elicit Acute Inflammatory Response in Fallopian Tube Organoids
To facilitate in vitro mechanistic studies in pelvic inflammatory disease and subsequent tubal factor infertility, we sought to establish patient...
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Somatic hypermutation profiles in stereotyped IGHV4-34 receptors from South American chronic lymphocytic leukemia patients
Chronic lymphocytic leukemia (CLL) is the most common mature B-cell neoplasm in the West. IGHV4-34 is one of the most frequently used genes in CLL...
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Naringin alleviates liver damage induced by D-galactosamine (D-gal) in mice through down-regulation of CYP2E1 and P53 hyperactivity
Cytochrome P450 2E1 (CYP2E1) plays an important role in liver damage. However, it is still unclear how CYP2E1 transcriptional regulation works....
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CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression
Kelch superfamily involves a variety of proteins containing multiple kelch motif and is well characterized as substrate adaptors for CUL3 E3 ligases,...
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Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation
BackgroundInsulin-like growth factor-1 (IGF-1) has the potential to be used for osteoarthritis (OA) treatment but has not been evaluated in clinics...
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Frontiers in pathophysiology and management of thrombotic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura (TTP) is a fatal disease in which platelet-rich microthrombi cause end-organ ischemia and damage. TTP is caused...
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Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit
Intellectual disability (ID) is a common neurodevelopmental disorder that can arise from genetic mutations ranging from trisomy to single nucleotide...
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Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma
BackgroundIn gastric solid-type poorly differentiated adenocarcinoma (PDA), the role of microsatellite instability and immune escape mechanism...
