Search
Search Results
-
Lack of Pharmacokinetic Interactions Between Steady-State Zonisamide and Valproic Acid in Patients with Epilepsy
ObjectivesThis study evaluated the effect of the addition of zonisamide on valproic acid (valproate sodium) pharmacokinetics under steady-state...
-
Zonisamide
AbstarctZonisamide (Zonegran®, Excegran®) is a new-generation, broad-spectrum antiepileptic drug (AED) currently approved as adjunctive therapy for...
-
Pharmacological and Behavioral Characteristics of Interactions between Vigabatrin and Conventional Antiepileptic Drugs in Pentylenetetrazole-Induced Seizures in Mice: An Isobolographic Analysis
To characterize the anticonvulsant effects and types of interactions exerted by mixtures of vigabatrin (VGB) and conventional antiepileptic drugs...
-
A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects
BACKGROUND: Treatment of obese subjects with topiramate has recently been associated with significant weight loss in a 6-month dose-ranging study.
OBJECTIVE:...
-
Substance use disorders and neurologic illness
Because of the high rates of substance use disorders among the general and clinical populations, and the abuse potential of many medications commonly...
-
Management of seizures in critically ill patients
For many neurologists, seizures in critically ill patients represent a difficult problem. Etiology can be elusive because of the complexity of the...
-
Special populations: The management of seizures in HIV-positive patients
An increasing percentage of patients with new-onset seizures are HIV positive. The evaluation and management is distinctly different from managing...
-
Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach
Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that...
-
Indications for Fetal Echocardiography
Congenital heart disease is one of the most common congenital malformations diagnosed in liveborns. As more women undergo prenatal diagnosis, the...
-
Chronic daily headache
The therapy of chronic daily headache (CDH) is complex and involves a combination of drugs, supportive psychotherapy, nondrug therapy, “tender-loving...
-
HRCT in children: technique and indications
High-resolution computed tomography (HRCT) is a very important diagnostic tool, which improves our understanding of many lung diseases in children....
-
Health-care Utilization among Mothers and Infants Following Cocaine Exposure
OBJECTIVE: To examine utilization of health-care resources among mothers and infants following cocaine use during pregnancy.
DESIGN: Prospective...
-
The Diverse Roles of Anticonvulsants in Bipolar Disorders
Anticonvulsant drugs (ACs) have diverse antiseizure, psychotropic, and biochemical effects. Carbamazepine and valproate have mood-stabilizing...
-
Effect of raloxifene on bone mineral density and biochemical markers of bone turnover in Japanese postmenopausal women with osteoporosis: results from a randomized placebo-controlled trial
The safety and efficacy of raloxifene, a selective estrogen receptor modulator (SERM), has been studied extensively in large, global clinical trials....
-
Vagus nerve stimulation as treatment for epileptic seizures
Vagus nerve stimulation is a unique therapy for epileptic seizures. Two randomized controlled trials in patients with medically refractory partial...
-
Tiagabine Synergistically Interacts with Gabapentin in the Electroconvulsive Threshold Test in Mice
Polytherapy, based on the rational combining of antiepileptic drugs (AEDs), is required for patients with drug-resistant epilepsy. In such cases, the...
-
Melatonin, circadian rhythms, and sleep
Experimental data show a close relationship among melatonin, circadian rhythms, and sleep. Low-dose melatonin treatment, increasing circulating...