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Serum soluble α-Klotho levels in patients with diabetic nephropathy
Abstract BackgroundThe study aimed to determine the variability in the stages of diabetic nephropathy by examining specific biochemical functions...
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Urea cycle disorders in Argentine patients: clinical presentation, biochemical and genetic findings
BackgroundThe incidence, prevalence, and molecular epidemiology of urea cycle disorders (UCDs) in Argentina remain underexplored. The present study...
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Therapeutic efficacy of proton pump inhibitor (omeprazole) on cryptosporidiosis parvum in immunosuppressed experimental mice
Cryptosporidiosis is one of the most frequent food and water-borne diseases. The disease might be life-threatening in immunosuppressed patients....
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Effectiveness and safety of intraoperative intraperitoneal 5-Fu drug implantation in patients with colorectal cancer: a retrospective cohort study
PurposeThe purpose of this clinical study was to evaluate the efficacy and safety of intraoperative chemotherapy (IOC) with intraoperative...
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Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker
BackgroundOxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD), prompting the exploration of antioxidants as a...
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Renal-protective effects of Chinese medicinal herbs and compounds for diabetic kidney disease in animal models: protocol for systematic review and meta-analysis
BackgroundDiabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The...
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Prevalence of, association with, severity of, and prognostic role of serum hemoglobin level in acutely decompensated heart failure patients
BackgroundThe role of hemoglobin (Hb) level in the short-term prognosis of patients with acute decompensated heart failure (ADHF) remains a matter of...
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Metabolic profile and gene expression pattern of cytokines and antioxidants markers during different physiological stages in Barki ewes
BackgroundIn livestock, identifying the physiological and reproductive stages is valuable in guiding management decisions related to nutrition,...
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In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy
In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and...
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The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis
AimCannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect...
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Assessment of renal function indexes in methamphetamine or tramadol intoxication adults to the emergency departments: a systematic review and meta-analysis
BackgroundRenal dysfunction is one of the adverse effects observed in methamphetamine (MET) or tramadol abusers. In this study, we aimed to review...
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Cytoprotective potential of the aqueous extract from Bridelia ferruginea stem bark against experimental cadmium-induced hepato-renal toxicity in Wistar rat
Cadmium (Cd), a non-redox metal, has been described as an environmental toxicant that poses a great threat to human health. Therefore, this study...
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Hyperammonemia in a pregnant woman with citrullinemia type I: a case report and literature review
BackgroundCitrullinemia type I (CTLN1) is a rare urea cycle disorder (UCD) with few adult cases described so far. Diagnosis of late-onset CTLN1 is...
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High protein intake on later outcomes in preterm children: a systematic review and meta-analysis
BackgroundAppropriate protein intake is crucial for growth and development in children born preterm. We assessed the effects of high (HP) versus low...
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Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
In recent years, the increase in blood pressure at high altitudes has become an interesting topic among high-altitude researchers. In our animal...
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A Genetic and Immunohistochemical Analysis of Helicobacter pylori Phenotypes and p27 Expression in Adenocarcinoma Patients in Jordan
Stomach (gastric) cancer is one of the most prevalent and deadly cancers worldwide and most gastric cancers are adenocarcinomas. Based on prior...
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Incidence, predictors, and short-term outcomes of acute kidney injury in children with diabetic ketoacidosis: a systematic review
BackgroundOne-third of children with type 1 diabetes mellitus manifest with diabetic ketoacidosis (DKA). Most children presenting with DKA are in a...
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Transforming growth factor-β1: relation between its single-nucleotide genetic variants and sickle cell nephropathy
BackgroundSickle cell nephropathy is a complication of sickle cell disease characterized by functional abnormalities of the kidney and glomeruli. Our...
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Gentamicin-induced acute nephrotoxicity counteraction using Boerhaavia diffusa in Swiss albino mice
Disruption of homeostasis, detoxification and excretion in kidney functions by endogenous or exogenous toxicants results in the occurrence of...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...