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Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated...
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Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI
PurposeProviding additional insights on the efficacy of human nuclear transfer (NT). Here, and earlier, NT has been applied to minimize transmission...
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Sexual dimorphism in mitochondrial dysfunction and diabetes mellitus: evidence from a population-based cohort study
BackgroundPathophysiological mechanisms underlying sex-based differences in diabetes remain poorly understood. Mitochondrial metabolite methylmalonic...
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Association between mitochondrial DNA D-loop region polymorphisms and endometriosis in a Chinese population
ObjectiveTo investigate the correlation between endometriosis and mitochondrial DNA (mtDNA) D-loop single nucleotide polymorphisms (SNPs) and...
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A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients: case report and functional studies
BackgroundMT-ATP6 is a mitochondrial gene which encodes for the intramembrane subunit 6 (or A) of the mitochondrial ATP synthase, also known asl...
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A preliminary analysis of mitochondrial DNA atlas in the type 2 diabetes patients
BackgroundType 2 diabetes (T2D), one of the most common metabolic diseases, is the result of insulin resistance or impaired insulin secretion due to...
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Mitochondrial DNA control region variation in a population sample from Thailand
Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total...
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Mature oocyte dysmorphisms may be associated with progesterone levels, mitochondrial DNA content, and vitality in luteal granulosa cells
PurposeTo identify whether follicular environment parameters are associated with mature oocyte quality, embryological and clinical outcomes.
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Healthcare resource utilization of patients with mitochondrial disease in an outpatient hospital setting
Background and objectivesMitochondrial diseases present as multi-system disorders requiring a comprehensive multidisciplinary approach. The data on...
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Mitochondrial DNA sequence variation and risk of meningioma
BackgroundRisk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation....
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Implications of mitochondrial DNA variants in pediatric B-cell acute lymphoblastic leukemia
BackgroundResearch on the role of variations in the mitochondrial genome in pathogenesis of acute lymphoblastic leukemia (ALL) has been unfolding at...
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Spectrum of mitochondrial genomic variation in parathyroid neoplasms
PurposeMitochondrial DNA (mtDNA) variations have been implicated in various cancer types. Several attempts have been made in benign parathyroid...
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Study of 17 X-STRs in Native American and Mestizo populations of Central America for forensic and population purposes
In the present work, an extensive analysis of the X-chromosomal pool of Native American and Mestizo groups of Central America (Guatemala, El...
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Variants in mitochondrial disease genes are common causes of inherited peripheral neuropathies
BackgroundPeripheral neuropathies in mitochondrial disease are caused by mutations in nuclear genes encoding mitochondrial proteins, or in the...
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Oxidative Stress, Mitochondrial Dysfunction, and Premature Ageing in Severe Acute Malnutrition in Under-Five Children
ObjectivesTo assess oxidative stress, mitochondrial dysfunction, and premature ageing in children with severe acute malnutrition (SAM).
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Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
BackgroundThere is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial...
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Exophthalmos associated with chronic progressive external ophthalmoplegia
PurposeChronic progressive external ophthalmoplegia (CPEO) is a mitochondrial disease characterized by slowly progressive ptosis and limitations in...
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The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling
Due to the formation of the Qiongzhou Strait by climate change and marine transition, Hainan island was isolated from the mainland southern China...
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Small Peptides from Periplaneta americana Inhibits Oxidative Stress-Induced KGN Cell Apoptosis by Regulating Mitochondrial Function Through Bcl2L13
This study examined the protective effects of small peptides from Periplaneta americana against H 2 O 2 -induced mitochondrial injury in human ovarian...
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A Systematic Review on the Genetic Contribution to Tinnitus
PurposeTo assess the available evidence to support a genetic contribution and define the role of common and rare variants in tinnitus.
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