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Cardiovascular remodeling as a result of fibroblast growth factor-23 (FGF-23)/Klotho imbalance in patients with CKD
BackgroundIn chronic kidney disease (CKD) cardiovascular remodeling (CVR) is very frequent compared with general population and, as suppose, may be...
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Enhancement of Apo2L/TRAIL signaling pathway receptors by the activation of Klotho gene with CRISPR/Cas9 in Caco-2 colon cancer cells
Human Klotho gene has many known functions such as anti-aging and anti-tumor, and decreased expression of this gene causes malignant formations in...
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Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies
Type 2 diabetes mellitus (T2DM) has become a global health problem with no cure. Despite lifestyle modifications and various pharmaceutical options,...
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Klotho protects against diabetic kidney disease via AMPK- and ERK-mediated autophagy
BackgroundDiabetic kidney disease (DKD) is a serious complication of diabetes mellitus and results in serious public health problems. Although a...
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Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study
BackgroundFibroblast growth factor-23 (FGF23) and α-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc...
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Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case–control study
PurposeTo evaluate circulating soluble α-klotho (sαKL) levels in GHD children before and after 12 months of GH treatment (GHT).
Methods ...
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Reduced fibroblast growth factor 21 and β-Klotho secretion in untreated congenital isolated GH deficiency
PurposesIncreasing evidence suggests that the FGF-Klotho endocrine system and the somatotropic system (pituitary and extra-pituitary GH) may have...
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Prognostic Value of Serum Soluble Klotho and Fibroblast Growth Factor-23 in Multiple Myeloma Patients
Multiple myeloma is the plasma cell malignancy in which bone involvement is common. The Fibroblast growth factor-23 (FGF-23)/Klotho pathway plays a...
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Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth
BackgroundKlotho is an anti-aging protein mainly expressed in the kidneys with a smaller amount expressed in adipose tissue. Klotho effects include...
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Mutation of Klotho rs3752472 protect the kidney from the renal epithelial cell injury caused by CaOx crystals through the Wnt/β-catenin signaling pathway
Calcium oxalate (CaOx) is a major contributor to urolithiasis, one of the most common urological diseases. Our previous study has shown that Klotho ...
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Evaluation of serum and aqueous humor klotho levels in pseudoexfoliation syndrome, pseudoexfoliation and primary open-angle glaucoma
PurposeThe aim of our study was to compare klotho in the serum and aqueous humor of patients with primary open-angle glaucoma (POAG),...
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Exercise intensity regulates cytokine and klotho responses in men
BackgroundShort-term exercise training programs that consist of moderate intensity endurance training or high intensity interval training have become...
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Body composition, adipokines, FGF23-Klotho and bone in kidney transplantation: Is there a link?
BackgroundKidney transplantation—associated mineral and bone disorder (KT-MBD) still represents a black box on the long-term due to scarce available...
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Fibroblast growth factor 23—Klotho and hypertension: experimental and clinical mechanisms
Hypertension (HTN) and chronic kidney disease (CKD) are increasingly recognized in pediatric patients and represent risk factors for cardiovascular...
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Klotho gene polymorphism in renal stone formers from Northwestern India
Klotho gene is an important gene involved in calcium homeostasis, and polymorphisms of this gene may render the individual prone to renal stone...
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Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho
Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these...
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Serum cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, klotho and fibroblast growth factor-23 in the early prediction of acute kidney injury associated with sepsis in a Chinese emergency cohort study
BackgroundAcute kidney injury (AKI) is a common and critical complication of sepsis, and is associated with unacceptable morbidity and mortality....
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The Emerging Key Role of Klotho in the Hypothalamus–Pituitary–Ovarian Axis
The hypothalamus–pituitary–ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead...
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Serum Klotho levels in primary hyperparathyroidism patients before and after parathyroidectomy
PurposeTo investigate Klotho level and its association with biochemical indices of primary hyperparathyroidism (PHPT).
MethodsFifty PHPT patients...
