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Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
The amyloid cascade hypothesis assumes that the development of Alzheimer’s disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid...
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The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment
ZBTB18/RP58 (OMIM *608433) is one of the pivotal genes responsible for 1q43q44 microdeletion syndrome (OMIM #612337) and its haploinsufficiency...
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AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse model
Hyperuricemia can induce acute and chronic kidney damage, but the pathological mechanism remains unclear. The potential role of AMP-activated protein...
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Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Aims/hypothesisGlucagon-expressing pancreatic alpha cells have attracted much attention for their plasticity to transdifferentiate into...
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ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway
BackgroundApart from the current understanding of enzyme function, the mechanism of ectonucleotide pyrophosphatase/phosphodiesterase 1 ( Enpp1 )...
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Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2 , leading to increased red blood cell (RBC)...
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Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8mnd mice
BackgroundCLN8-Batten disease (CLN8 disease) is a rare neurodegenerative disorder characterized phenotypically by progressive deterioration of motor...
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Genetically-engineered mouse models of small cell lung cancer: the next generation
Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in dire need of new and effective therapeutic approaches....
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Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity
ANK3 is a leading bipolar disorder (BD) candidate gene in humans and provides a unique opportunity for studying epilepsy-BD comorbidity. Previous...
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TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells
Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid...
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Deep phenoty** reveals movement phenotypes in mouse neurodevelopmental models
BackgroundRepetitive action, resistance to environmental change and fine motor disruptions are hallmarks of autism spectrum disorder (ASD) and other...
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Genetically engineered mouse models of head and neck cancers
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone....
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Effects of STAT Inhibitors in Mouse Models of Endometriosis
The signal transducer and activator of transcription (STAT) pathway, which regulates cell proliferation and immunity, has been implicated in chronic...
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Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of hypertension induced by angiotensin II
Fruit from the Prunus mume tree is a traditional food in Japan. Recently, bainiku-ekisu, an infused juice concentrate of Japanese Prunus mume , is...
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Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model
BackgroundAsthma is a major cause of morbidity and mortality in humans. The mechanisms of asthma are still not fully understood. Leukocyte-specific...
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Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53Y220C mutant: bioinformatics and experimental evidence
Mutations in the tumor suppressor protein p53 is a prevalent feature in majority of cancers resulting in inactivation of its activities related to...
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Chronic intermittent hypoxia induces cognitive impairment in Alzheimer’s disease mouse model via postsynaptic mechanisms
PurposeObstructive sleep apnea (OSA) is highly comorbid with Alzheimer’s disease (AD) and may represent a risk factor for inducing or accelerating...
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Lymphatic Drainage System and Lymphatic Metastasis of Cancer Cells in the Mouse Esophagus
BackgroundLymphatic metastasis is commonly seen in patients with esophageal squamous cell carcinoma (ESCC). Both lymphatic metastasis and the number...
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[18F]-FDG uptake in brain slices prepared from an aged mouse model of Alzheimer’s disease using a dynamic autoradiography technique
Objective2-[ 18 F]fluoro-2-deoxy- d -glucose positron emission tomography ([ 18 F]-FDG-PET) is a imaging modality that has been used to measure of glucose...
