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Estrogen receptor-negative/progesterone receptor-positive and her-2-negative breast cancer might no longer be classified as hormone receptor-positive breast cancer
BackgroundThe single progesterone receptor (PR)-positive phenotype (estrogen receptor (ER)-/PR + , sPR positive) is an infrequent and independent...
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Reasons for non-disclosure of HIV-Positive status to healthcare providers: a mixed methods study in Mozambique
BackgroundNon-disclosure of known HIV status by people living with HIV but undergoing HIV testing leads to waste of HIV testing resources and...
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Individualizing Curative-Intent Therapy in HER2-Positive Early-Stage Breast Cancer
Human epidermal growth factor receptor 2-positive (HER2+) breast cancers have been historically considered an aggressive entity with high rates of...
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Can contralateral lymph-node metastases be ruled out in prostate cancer patients with only unilaterally positive prostate biopsy?
PurposeOur study evaluated the diagnostic benefits of bilateral pelvic lymphadenectomy in prostate cancer patients with unilaterally positive...
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In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors
BackgroundChimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, while the...
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Is there any prognostic significance in pleural involvement and/or effusion in patients with ALK-positive NSCLC?
PurposeAnaplastic lymphoma kinase (ALK) mutations occurs in approximately 3–5% of patients with non-small cell lung cancer (NSCLC). Pleural...
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A Multi-institutional Analysis of Factors Influencing the Rate of Positive MRI Biopsy Among Women with Early-Stage Breast Cancer
BackgroundThe use of preoperative magnetic resonance imaging (MRI) for early-stage breast cancer (ESBC) is increasing, but its utility in detecting...
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Prognostic Heterogeneity Between Oral Tongue and Gingivobuccal Tumours Based on Lymph Node Ratio and Number of Positive Nodes: A Survival Analysis
IntroductionLymph node ratio (LNR) and number of pathological positive nodes (pN) have shown better prognostic prediction compared to laterality,...
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Clinical observational study on the efficacy of induction chemotherapy sequential concurrent radiotherapy combined with targeted therapy in patients with locally advanced EGFR-positive nasopharyngeal carcinoma: prediction model construction and efficacy testing
ObjectiveTo establish a nomogram for prediction of prognosis in EGFR-positive advanced nasopharyngeal carcinoma (NPC) patients who were treated with...
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POStoperative INTELLiVENT-adaptive support VEntilation in cardiac surgery patients (POSITiVE) II—study protocol of a randomized clinical trial
BackgroundOne single-center randomized clinical trial showed that INTELLiVENT-adaptive support ventilation (ASV) is superior to conventional...
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Clinical risk prediction model and external validation of positive surgical margin in laparoscopic radical prostatectomy based on MRI lesion location
ObjectiveTo clarify the composition of lesions in different magnetic resonance imaging (MRI) partitions of positive surgical margins (PSM) after...
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Neurovascular Compression-Induced Intracranial Allodynia May Be the True Nature of Migraine Headache: an Interpretative Review
Purpose of ReviewSurgical deactivation of migraine trigger sites by extracranial neurovascular decompression has produced encouraging results and...
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Positive predictive value of urine analysis with reflex criteria at a large community hospital
Introduction and hypothesisUrine analysis with reflex to culture (URTC) is employed as a diagnostic aid for urinary tract infections (UTIs). Criteria...
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The “bubbles”-study: validation of ultra-short scales for the assessment of positive mental health, life satisfaction, and perceived social support
AimThe positive dimension of mental health should be considered to assess the complete state of a person’s mental health and to protect it. Very...
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A positive association between BMI and kidney stones among the diabetic population: a cross-sectional study from NHANES
BackgroundIn the past, research has shown that a higher body mass index (BMI) is one of the variables that increase the likelihood of kidney stones;...
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Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab
BackgroundThe aim of this study was to explore the clinical utility of serum HER2 extracellular domain (sHER2 ECD) using data from a clinical trial...
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Transcranial Magnetic Stimulation in the Treatment of Positive, Negative, and Cognitive Symptoms of Psychosis
Purpose of ReviewThe aim of this review is to examine the clinical efficacy of transcranial magnetic stimulation (TMS) as an interventional...
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Analysis of false positive PI-RADS 4 lesions: experience from a single nonacademic center using cognitive fusion
BackgroundWe evaluated pathological findings in targeted biopsies of PI-RADS4 and PI-RADS5 lesions, and clinical data that could predict those...
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Investigating the combined and unique contributions of positive psychological traits to sleep and exploring emotion regulation as a common mediator
The identification of variables which facilitate good quality and quantity sleep represents an important step in tackling the current global sleep...
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Determinants of positive rigid bronchoscopy for suspected organic foreign body aspiration in children younger than five years
PurposeRigid bronchoscopy is widely used for diagnosis and treatment of foreign body aspiration (FBA) in children, but negative results can be...
