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Prognostic value and characterization of NTRK1 variation by fluorescence in situ hybridization in esophageal squamous cell carcinoma
PurposeRearrangement of the neurotrophic tyrosine kinase receptor ( NTRK ) 1 gene is a target of tropomyosin receptor kinase A (TRKA) inhibitors, and...
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Allergen Stability in Food Allergy: A Clinician’s Perspective
Purpose of ReviewThe globally rising food allergy prevalence is associated with the urgent need for new disease prevention methods, efficient...
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BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model
BackgroundPreclinical studies have indicated that the ketamine metabolite ( 2R,6R )-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug...
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The association between diabetes and obesity with Dengue infections
Dengue, an arboviral disease is a global threat to public health as the number of Dengue cases increases through the decades and this trend is...
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The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum
Heart failure (HF) remains a major cause of mortality and morbidity worldwide. Understanding the genetic basis of HF allows for the development of...
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The Molecular Allergology User’s Guide 2.0: Update on relevant new content
The first Molecular Allergology User’s Guide was published in 2016 and quickly became a key reference for many clinicians and scientists worldwide....
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TRK Fusion Cancer: Patient Characteristics and Survival Analysis in the Real-World Setting
BackgroundNeurotrophic tyrosine receptor kinase ( NTRK ) gene fusions are oncogenic drivers in various tumor types. While NTRK gene fusions are...
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Eosinophilia and potential antibody cross-reactivity between parasites in a child with pinworm and immune dysregulation: a case report
BackgroundIntestinal parasitic infections are common in humans, especially among young children. These conditions are often asymptomatic and...
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Aficamten: A Breakthrough Therapy for Symptomatic Obstructive Hypertrophic Cardiomyopathy
Aficamten is a novel cardiac myosin inhibitor that has demonstrated its ability to safely lower left ventricular outflow tract (LVOT) gradients and...
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Imported allergens in Italy: an emerging issue
Imported allergens are involved in many allergic reactions, with unexpected and unusual implications. They can be involved in develo** asthma,...
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Cardiovascular biomarkers: exploring troponin and BNP applications in conditions related to carbon monoxide exposure
BackgroundThe diagnosis and prognosis of cardiovascular disorders are greatly aided by cardiovascular biomarkers. The uses of troponin and B-type...
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C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens
Purpose of ReviewAllergic diseases represent a major health problem of increasing prevalence worldwide. In allergy, dendritic cells (DCs) contribute...
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RAS and Other Molecular Targets in Pancreatic Cancer: The Next Wave Is Coming
Since the discovery of oncogenes in the 1970s, cancer doctors and researchers alike have understood the promise of discovering drugs to block the...
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Personalisierte Medizin in der Onkologie
Due to the considerable technological progress in molecular and genetic diagnostics as well as increasing insights into the molecular pathogenesis of...
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Tücken der Diagnostik der Hausstaubmilbenallergie
House dust mite (HDM) is the most significant indoor allergen, responsible for not only many cases of rhinoconjunctivitis but also for many cases of...
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Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice
Chronic stress plays a critical role in the etiology of sporadic Alzheimer’s disease (AD). However, there are currently no effective drugs that can...
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Calcium sensing and signaling are impaired in the lumbar spine of a rat model of congenital kyphosis
PurposeKyphosis involves spines curving excessively backward beyond their physiological curvature. Although the normal structure of the spinal...
