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Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
BackgroundFibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease...
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Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy
BackgroundDilation may be the first right ventricular change and accelerates the progression of threatening ventricular tachyarrhythmias and heart...
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Single-cell combined bioinformatics analysis: construction of immune cluster and risk prognostic model in kidney renal clear cells based on CD8+ T cell-associated genes
BackgroundKidney cancer is an immunogenic solid tumor, characterized by high tumor burden and infiltration of CD8 + T cells. Although immunotherapy...
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The heterogeneity of breast cancer metastasis: a bioinformatics analysis utilizing single-cell RNA sequencing data
PurposeBreast cancer is a common malignancy in women, and its metastasis is a leading cause of cancer-related deaths. Single-cell RNA sequencing...
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Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-cell RNA sequencing (scRNA-seq) has enabled the profiling of...
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Single-cell analysis of peripheral CD8+ T cell responses in patients receiving checkpoint blockade immunotherapy for cancer
Checkpoint blockade immunotherapy has become a first-line treatment option for cancer patients, with success in increasingly diverse cancer types....
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Single-cell RNA sequencing reveals hub genes of myocardial infarction-associated endothelial cells
BackgroundMyocardial infarction (MI) is a cardiovascular disease that seriously threatens human health. Dysangiogenesis of endothelial cells (ECs)...
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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis
The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported...
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Enabling methanol fixation of pediatric nasal wash during respiratory illness for single cell sequencing in comparison with fresh samples
BackgroundLower respiratory tract infection (LRTI) including pneumonia, bronchitis, and bronchiolitis is the sixth leading cause of mortality around...
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Integrated single-cell RNA sequencing analysis reveals a mesenchymal stem cell-associated signature for estimating prognosis and drug sensitivity in gastric cancer
BackgroundMesenchymal stem cells (MSCs) play an important role in regulating all stages of the immune response, angiogenesis, and transformation of...
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Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
BackgroundGout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to...
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Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer
The heterogeneity and the complex cellular architecture have a crucial effect on breast cancer progression and response to treatment. However,...
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Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance
Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive epithelial cancer with poor overall response rates to checkpoint inhibitor therapy...
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Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
CD8+ T lymphocytes are critical in the immune response against neoplasms, yet the prognostic relevance of CD8+ T cell-associated genes in...
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Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity
Single-cell transcriptomic profiles analysis has proposed new insights for understanding the behavior of human gastric cancer (GC). GC offers a...
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Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the investigation of tumor...
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Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI)
Genomic tumor testing (GTT) is an emerging technology aimed at identifying variants in tumors that can be targeted with genomically matched drugs....
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Applications of single-cell sequencing in cancer research: progress and perspectives
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and metabolomics sequencing, is a powerful tool to decipher the...
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Single-cell landscape of undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive malignant soft tissue tumor with a poor prognosis; however, the identity and...
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Network analysis for estimating standardization trends in genomics using MEDLINE
BackgroundBiotechnology in genomics, such as sequencing devices and gene quantification software, has proliferated and been applied to clinical...
