Search
Search Results
-
Levetiracetam and Midazolam vs Midazolam Alone for First-Line Treatment of Children With Generalized Convulsive Status Epilepticus (Lev-Mid Study): A Randomized Controlled Trial
BackgroundBenzodiazepines are the first-line anti-seizure medication (ASM) for generalized convulsive status epilepticus (GCSE), but they fail to end...
-
Sustained effects of single doses of classical psychedelics in humans
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD,...
-
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Ketamine is an open channel blocker of ionotropic glutamatergic N -Methyl- D -Aspartate (NMDA) receptors. The discovery of its rapid antidepressant...
-
Alterations in brain synaptic proteins and mRNAs in mood disorders: a systematic review and meta-analysis of postmortem brain studies
AbstractThe pathophysiological mechanisms underlying bipolar (BD) and major depressive disorders (MDD) are multifactorial but likely involve synaptic...
-
Application of positron emission tomography in psychiatry—methodological developments and future directions
Mental disorders represent an increasing source of disability and high costs for societies globally. Molecular imaging techniques such as positron...
-
Imaging synaptic density in depression
Major depressive disorder is a prevalent and heterogeneous disorder with treatment resistance in at least 50% of individuals. Most of the initial...
-
Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia
PurposeMammographic density (MD), after accounting for age and body mass index (BMI), is a strong heritable risk factor for breast cancer....
-
Potential of neuroimaging as a biomarker in amyotrophic lateral sclerosis: from structure to metabolism
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration. The development of ALS...
-
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced...
-
Synaptic vesicle protein 2A tumoral expression predicts levetiracetam adverse events
ObjectiveThe efficacy of levetiracetam (LEV) in controlling seizures in patients with brain tumor-related epilepsy (BTRE) depends on tumoral...
-
Structural connectivity as a predictive factor for responsiveness to levetiracetam treatment in epilepsy
PurposeTo investigate whether structural connectivity or glymphatic system function is a potential predictive factor for levetiracetam (LEV) response...
-
Status epilepticus in the ICU
Status epilepticus (SE) is a common medical emergency associated with significant morbidity and mortality. Management that follows published...
-
Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
[ 11 C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [ 11 C]UCB-J PET may serve as an in vivo marker of...
-
Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Background and ObjectiveMost second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a...
-
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease
The risk of develo** Alzheimer’s disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly cognitively healthy...
-
Rapid switching from levetiracetam to brivaracetam in pharmaco-resistant epilepsy in people with and without intellectual disabilities: a naturalistic case control study
BackgroundApproximately one quarter of people with an intellectual disability (PwID) have epilepsy of whom nearly three-quarters are...
