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MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming
BackgroundMicroRNA-612 (miR-612) has been proven to suppress EMT, stemness, and tumor metastasis of hepatocellular carcinoma (HCC) via PI3K/AKT2 and...
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Isolation and characterization of exosomes for cancer research
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting...
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γδ T cells: origin and fate, subsets, diseases and immunotherapy
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune...
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Noncoding RNAs: the shot callers in tumor immune escape
Immunotherapy, designed to exploit the functions of the host immune system against tumors, has shown considerable potential against several...
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Clinical utility of circulating non-coding RNAs — an update
Over the past decade, the amount of research and the number of publications on associations between circulating small and long non-coding RNAs...
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Long non-coding RNAs in genitourinary malignancies: a whole new world
Long non-coding RNAs (lncRNAs) are regulators of cellular machinery that are commonly dysregulated in genitourinary malignancies. Accordingly, the...
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Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression
BackgroundColorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic...