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Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
IntroductionThe aim of this study was to assess the efficacy and safety of 15% azelaic acid (AzA) gel in treating acne-induced post-inflammatory...
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Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression
BackgroundTo establish a treatment option for liver fibrosis, the possibility of the drug repurposing theory was investigated, with a focus on the...
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Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication
According to a hierarchical model, targeting leukemia-initiating cells (LICs) was speculated to achieve complete remission (CR) or cure. Nonetheless,...
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The etiology of congenital diaphragmatic hernia: the retinoid hypothesis 20 years later
AbstractCongenital diaphragmatic hernia (CDH) is a severe birth defect and a major cause of neonatal respiratory distress. Impacting ~2–3 in 10,000...
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Potential molecular targets and drugs for basement membranes-related intervertebral disk degeneration through bioinformatics analysis and molecular docking
BackgroundThrough bioinformatics analysis to identify the hub genes of Intervertebral disc degeneration (IVDD) associated with basement membranes...
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Identification of potential diagnostic biomarkers and therapeutic targets for endometriosis based on bioinformatics and machine learning analysis
PurposeEndometriosis (EMs) is a major gynecological condition in women. Due to the absence of definitive symptoms, its early detection is very...
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Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
We stratified patients with newly diagnosed acute promyelocytic leukemia (APL) according to a white blood cell (WBC) count of ≥ 3 × 10 9 /L (high risk)...
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Medical treatment for ocular surface squamous neoplasia
Ocular surface squamous neoplasia (OSSN) is the most common non-melanocytic tumour of the ocular surface. Surgical excision with wide margins using...
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Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial
PurposeThe reported maximum tolerated dose (MTD) of single-agent belinostat is 1000 mg/m 2 given days 1–5, every 21 days. Pre-clinical evidence...
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Elevated Th17 cell proportion, related cytokines and mRNA expression level in patients with hypertension-mediated organ damage: a case control study
BackgroundImmune abnormalities and inflammatory responses play critical roles in progression of hypertension. Basic studies have confirmed that Th17...
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic...
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Ursonic acid from medicinal herbs inhibits PRRSV replication through activation of the innate immune response by targeting the phosphatase PTPN1
Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), has caused substantial economic losses to the global swine...
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Sustained-release drug delivery systems
The design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to...
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Evaluation of 30% supramolecular salicylic acid followed by 1565-nm non-ablative fractional laser on facial acne and subsequent enlarged pores
The treatment of acne vulgaris and enlarged pore remains challenging. The 30% supramolecular salicylic acid (SSA) is a newly developed form of SA...
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Palovarotene: First Approval
Palovarotene (Sohonos™) is an orally bioavailable selective retinoic acid receptor (RAR)γ agonist being developed by Ipsen for the reduction of...
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Butyrate: More Than a Short Chain Fatty Acid
Purpose of ReviewThe mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in...
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Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the develo** cerebellum
Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental syndromes characterized by social and communication impairment,...
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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia
The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a...
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Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA
Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death...
