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Consideration of methods for identifying mite allergens
House dust mites are small arthropods that produce proteins—found in their feces, body parts, and eggs—that are major triggers of human allergies...
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Modified Allergens for Immunotherapy
Purpose of ReviewDuring the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to...
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Targeting macrophage migration inhibitory factor (MIF): a promising therapy for inflammatory ocular diseases
Inflammatory ocular diseases are characterized by the presence of a persistent inflammatory response which cause tissue injury, decrease visual...
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Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?
Purpose of ReviewHereditary angioedema (HAE) is a disorder affecting bradykinin regulation presenting as recurrent cutaneous or mucosal swelling....
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Role of oncostatin M in the pathogenesis of vernal keratoconjunctivitis: focus on tissue remodeling
PurposeVernal keratoconjunctivitis (VKC) is a severe and recurrent allergic conjunctivitis, the mechanism of which is not well understood. In this...
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Serum interleukin 38 (IL-38) as a new potential biomarker of pediatric asthma
BackgroundBronchial asthma is considered the most prevalent chronic respiratory disease worldwide and is one of the main causes of hospitalization in...
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SIgA in various pulmonary diseases
Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the...
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Part I: Insect stings and bites—Beyond the realm of bee and wasp allergies
BackgroundInsects are a very diverse group of animals and valuable members of any ecosystem. Allergies to bees and wasps (order: Hymenoptera) are...
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Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness
ObjectiveS100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory activities. We previously...
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Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome
Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the...
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New Strategies for Prevention and Treatment of Insect Bite Hypersensitivity in Horses
Purpose of ReviewTreatment of equine insect bite hypersensitivity (IBH) needs to be improved. Allergen-specific immunotherapy (ASIT), the only...
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Design of a multi-epitope-based vaccine candidate against Bovine Genital Campylobacteriosis using a reverse vaccinology approach
BackgroundBovine Genital Campylobacteriosis (BGC), a worldwide distributed venereal disease caused by Campylobacter fetus subsp. venerealis ( Cfv ),...
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High mobility group box-1: a potential therapeutic target for allergic rhinitis
Allergic rhinitis (AR) is a prevalent chronic inflammatory disease of the nasal mucosa primarily characterized by symptoms, such as nasal itching,...
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Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease
BackgroundAsthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in...
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Immunotherapy Update: What Delivery Techniques Are Available?
Purpose of the ReviewTo summarize the different delivery techniques studied for the administration of allergen immunotherapy.
Recent Findings ... -
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
RationaleSevere asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an...
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New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic Signaling
Mast cells originate from the CD34 + /CD117 + hematopoietic progenitors in the bone marrow, migrate into circulation, and ultimately mature and reside...
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House dust mite sensitisation and association with atopic dermatitis in Brunei
IgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in...
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A Precision Medicine Approach to Rhinitis Evaluation and Management
Purpose of ReviewPrecision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. The PM approach focuses on the...
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Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses
BackgroundCulicoides hypersensitivity (CH) is induced in horses by salivary allergens of Culicoides midges. In Iceland, the causal Culicoides ...
