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Investigation of real-world heparin resistance and anticoagulation management prior to cardiopulmonary bypass: report from a nationwide survey by the Japanese Association for Thoracic Surgery heparin resistance working group
ObjectiveHeparin resistance is often encountered during cardiopulmonary bypass. Heparin dose and activated clotting time target values for the...
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Curation of myeloma observational study MALIMAR using XNAT: solving the challenges posed by real-world data
ObjectivesMAchine Learning In MyelomA Response (MALIMAR) is an observational clinical study combining “real-world” and clinical trial data, both...
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Real-world treatment patterns in patients with nontuberculous mycobacterial lung disease in the Netherlands based on medication dispensing data
PurposeReal-world data on antibiotic management of nontuberculous mycobacterial lung disease (NTM-LD) is limited for many countries. This study aimed...
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Potential Predictors of Response to CGRP Monoclonal Antibodies in Chronic Migraine: Real-World Data
Purpose of ReviewReal-world data (RWD) has identified potential predictors of response to anti-CGRP therapies in patients with chronic migraine (CM)....
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Effectiveness of oral semaglutide on glucose control and body weight up to 18 months: a multicenter retrospective real-world study
AimOral semaglutide, an innovative orally administered GLP-1 receptor agonist for type 2 diabetes (T2D) management was herein evaluated for its...
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Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study
This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive...
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Real-world data of cardio-oncologic interventions for cardiovascular adverse events with oral oncolytics
BackgroundOral cancer therapy-related cardiovascular (CV) toxicity has a wide variety of presentations including arrhythmia, cardiomyopathy, and...
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Real-World Treatment Patterns and Healthcare Resource Use for Ulcerative Colitis and Crohn’s Disease in Italy
IntroductionReal-world data are used to inform decision-makers and optimise therapeutic management for patients with ulcerative colitis (UC) and...
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Management strategies for intracranial progression in ALK-positive non-small cell lung cancer: a real-world cohort study
PurposeALK-positive NSCLC patients exhibit a particularly high propensity for the development of brain metastases. Current guidelines suggest transit...
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Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer’s Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project
The Real-World Implementation, Deployment, and Validation of Early Detection Tools and Lifestyle Enhancement (AD-RIDDLE) project, recently launched...
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Real-World Data on Therapies for Relapsed or Refractory Multiple Myeloma: Key Data from ASH 2023—A Podcast
Immunotherapies have significantly improved outcomes in patients with multiple myeloma yet maintaining a durable response in heavily pretreated...
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UroPredict: Machine learning model on real-world data for prediction of kidney cancer recurrence (UroCCR-120)
Renal cell carcinoma (RCC) is most often diagnosed at a localized stage, where surgery is the standard of care. Existing prognostic scores provide...
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Treatment-Related Cognitive Impairment in Patients with Prostate Cancer: Patients’ Real-World Insights for Optimizing Outcomes
Cognitive impairment (CI) is an issue that needs to be at the forefront of unmet healthcare needs in patients with prostate cancer (PCa) as it can...
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Real-world data of atezolizumab in patients with previously treated locally advanced or metastatic urothelial bladder cancer
BackgroundClinical trials of atezolizumab for locally advanced or metastatic urothelial bladder cancer (mUBC) report controversial efficacy data....
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Harnessing the Potential of Real-World Evidence in the Treatment of Colorectal Cancer: Where Do We Stand?
Treatment guidelines for colorectal cancer (CRC) are primarily based on the results of randomized clinical trials (RCTs), the gold standard...
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Real-World Clinical Experience of Oral Semaglutide in a Secondary Diabetes Clinic in the UK: A Retrospective Observational Study
IntroductionOral semaglutide improves cardiovascular risk factors in people with type 2 diabetes (T2D) in clinical trials, though real-world evidence...
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Real-World Outcomes of Trilaciclib Among Patients with Extensive-Stage Small Cell Lung Cancer Receiving Chemotherapy
IntroductionTrilaciclib was recently approved in the USA for reducing chemotherapy-induced myelosuppression (CIM) among adults with extensive-stage...
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Real-world accuracy of computed tomography in patients admitted with small bowel obstruction: a multicentre prospective cohort study
PurposeSmall bowel obstruction (SBO) is a common surgical emergency. Previous studies have shown the value computed tomography (CT) scanning in both...
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Promise of Real-World Evidence for Patient Centricity in Gulf Cooperation Council Countries: Call to Action
Presently, Gulf Cooperation Council countries are lagging in the generation of real-world data and use of real-world evidence for patient-centered...
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A sco** review on quality assessment tools used in systematic reviews and meta-analysis of real-world studies
Risk of bias tools is important in identifying inherent methodical flaws and for generating evidence in studies involving systematic reviews (SRs)...
